BENZYLOXYACETALDEHYDE DIETHYL ACETAL

Base Information

• Chemical Name: BENZYLOXYACETALDEHYDE DIETHYL ACETAL
• CAS No.: 78314-63-3
• Molecular Formula: C13H20O3
• Molecular Weight: 224.3
• Mol file: 78314-63-3.mol

Synonyms:BENZYLOXYACETALDEHYDE DIETHYL ACETAL;1-BENZYLOXY-2,2-DIETHOXYETHANE

Chemical Property of BENZYLOXYACETALDEHYDE DIETHYL ACETAL

Chemical Property:

• Refractive Index: n20/D 1.478(lit.)
• Boiling Point: 99-100 °C0.6 mm Hg(lit.)
• Flash Point: 175 °F
• PSA: 27.69000
• Density: 0.987 g/mL at 25 °C(lit.)
• LogP: 2.99240

Purity/Quality:

98%Min ^*data from raw suppliers

Benzyloxyacetaldehyde diethyl acetal 95% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BENZYLOXYACETALDEHYDE DIETHYL ACETAL

There total 6 articles about BENZYLOXYACETALDEHYDE DIETHYL ACETAL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

3-Benzyloxypropanal (19790-60-4) + orthoformic acid triethyl ester (122-51-0) → 3-benzyloxypropionaldehyde diethyl acetal (78314-63-3)

Guidance literature:

With zinc(II) chloride; for 1h; Ambient temperature;

DOI:10.1016/S0957-4166(00)80489-9

Reference yield: 86.0%

3,3-diethoxypropan-1-ol (16777-87-0) + benzyl bromide (100-39-0) → 3-benzyloxypropionaldehyde diethyl acetal (78314-63-3)

Guidance literature:

3,3-diethoxypropan-1-ol; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 1h; Inert atmosphere;

benzyl bromide; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

DOI:10.5012/bkcs.2010.31.9.2473

Reference yield: 71.0%

3-chloro-1,1-diethoxy-propane (35573-93-4) + benzyl alcohol (100-51-6,185532-71-2) → 3-benzyloxypropionaldehyde diethyl acetal (78314-63-3)

Guidance literature:

With sodium hydroxide; tetrabutyl hydrogen sulfate; In water; sodium chloride; 60 deg C, 12 h, then 100 deg C, 48 h;

DOI:10.1246/bcsj.58.2812

upstream raw materials:

3-Benzyloxypropanal

orthoformic acid triethyl ester

3-chloro-1,1-diethoxy-propane

benzyl alcohol

Downstream raw materials:

(1'S)-3-benzyloxy-1-ethoxypropyl 2,3,4,6-tetra-O-acetyl-β-D-glucopyranoside

(1'R)-3-benzyloxy-1-ethoxypropyl 2,3,4,6-tetra-O-acetyl-β-D-glucopyranoside

(1RS)-3-benzyloxy-1-ethoxypropyl 2,3,4,6-tetra-O-acetyl-α-D-mannopyranoside

3,3-diethoxypropan-1-ol

Refernces

• 1、 Uenishi,Motoyama,Takahashi. "Asymmetric synthesis of D- and L-2-deoxy-4-thioriboses". . p. 101 - 110. Retrieved 2007/10/02.
• 2、 Yamaura,Suzuki,Hashimoto,et al.. "A convenient synthesis of 6-hydroxy-7,9-bis(p-methoxybenzyl)-5-methylene-2-oxa-7,9-diazabicyclo[4.2 .2]decane-8,10-dione". . p. 2812 - 2820. Retrieved 2007/10/02.