3,3-DIETHOXY-1-PROPANOL

Base Information

• Chemical Name: 3,3-DIETHOXY-1-PROPANOL
• CAS No.: 16777-87-0
• Molecular Formula: C7H16 O3
• Molecular Weight: 148.202
• Hs Code.: 29094980
• Mol file: 16777-87-0.mol

Synonyms:Hydracrylaldehyde,diethyl acetal (8CI); 3,3-Diethoxypropan-1-ol; 3,3-Diethoxypropanol;3-Hydroxypropanal diethyl acetal; 3-Hydroxypropionaldehyde diethyl acetal;Propanal, 3-hydroxy-, diethyl acetal

Chemical Property of 3,3-DIETHOXY-1-PROPANOL

Chemical Property:

• Vapor Pressure: 0.149mmHg at 25°C
• Refractive Index: n20/D 1.421(lit.)
• Boiling Point: 190.1°Cat760mmHg
• PKA: 15.05±0.10(Predicted)
• Flash Point: 91.1°C
• PSA: 38.69000
• Density: 0.958g/cm³
• LogP: 0.76790
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

98%,99%, ^*data from raw suppliers

3,3-Diethoxy-1-propanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Total 1 MSDS from other Authors

Useful:

• Uses: 3,3-Diethoxy-1-propanol was used in the synthesis of α-acetal-poly(ethylene glycol) via reaction with potassium napthalide and ethylene oxide inside an UniLab Glovebox.

Technology Process of 3,3-DIETHOXY-1-PROPANOL

There total 8 articles about 3,3-DIETHOXY-1-PROPANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

3-benzyloxypropionaldehyde diethyl acetal (78314-63-3) → 3,3-diethoxypropan-1-ol (16777-87-0)

Guidance literature:

With ammonia; sodium; In tetrahydrofuran; at -78 ℃;

DOI:10.1016/S0957-4166(00)80489-9

Reference yield: 92.0%

ethyl 3,3-diethoxypropanoate (10601-80-6) → 3,3-diethoxypropan-1-ol (16777-87-0)

Guidance literature:

ethyl 3,3-diethoxypropanoate; With lithium aluminium tetrahydride; In tetrahydrofuran; at 10 - 20 ℃; for 1h;

With water; In tetrahydrofuran; for 2h; Product distribution / selectivity;

Reference yield:

acrylaldehyde diethyl acetal (3054-95-3) → 3,3-diethoxypropan-1-ol (16777-87-0) + propylene glycol monoethyl ether (1569-02-4)

Guidance literature:

With sodium hydroxide; dihydrogen peroxide; bis-(1,2-dimethylpropyl)borane; Product distribution; 1)THF, 0 deg C, 7 h;

DOI:10.1021/jo00333a009

upstream raw materials:

3-chloro-1,1-diethoxy-propane

ethyl 3,3-diethoxypropanoate

3-Hydroxypropanal

orthoformic acid triethyl ester

Downstream raw materials:

3-Hydroxypropanal

3,3-diethoxypropanal

3-ethoxyacrolein

Glyoxal

Refernces

• 1、 Uenishi,Motoyama,Takahashi. "Asymmetric synthesis of D- and L-2-deoxy-4-thioriboses". . p. 101 - 110. Retrieved 2007/10/02.
• 2、 Uenishi, Jun'ichi,Motoyama, Mitsuhiro,Nishiyama, Yoshitaka,Wakabayashi, Shoji. "Stereocontrolled Preparation of Cyclic Xanthate; a Novel Synthetic Route to 4-Thiofuranose and 4'-Thionucleoside". . p. 1421 - 1422. Retrieved 2007/10/02.