ethyl 3-amino-3-(4-methoxyphenyl)propanoate hydrochloride

Base Information

• Chemical Name: ethyl 3-amino-3-(4-methoxyphenyl)propanoate hydrochloride
• CAS No.: 167887-35-6
• Molecular Formula: C12H18ClNO3
• Molecular Weight: 259.72922
• Mol file: 167887-35-6.mol

Synonyms:ethyl 3-amino-3-(4-methoxyphenyl)propanoate hydrochloride

Chemical Property of ethyl 3-amino-3-(4-methoxyphenyl)propanoate hydrochloride

Chemical Property:

• Melting Point: 133-137 °C

Purity/Quality:

98%min ^*data from raw suppliers

Ethyl 3-amino-3-(4-methoxyphenyl)propanoatehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 3-amino-3-(4-methoxyphenyl)propanoate hydrochloride

There total 6 articles about ethyl 3-amino-3-(4-methoxyphenyl)propanoate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

ethanol (64-17-5) + 3-amino-3-(4-methoxyphenyl)propanoic acid hydrochloride (38499-45-5) → 3-amino-3-(4-methoxyphenyl)propionic acid ethyl ester hydrochloride (167887-35-6)

Guidance literature:

ethanol; With thionyl chloride; at -10 ℃; for 0.5h;

3-amino-3-(4-methoxyphenyl)propanoic acid hydrochloride; In ethanol; at -10 - 40 ℃;

DOI:10.1016/j.tet.2005.04.077

Reference yield: 59.0%

→ 3-amino-3-(4-methoxyphenyl)propionic acid ethyl ester hydrochloride (167887-35-6)

Guidance literature:

Reference yield:

diethyl 2-(1-(N-tert-butoxycarbonylamino)-1-(4-methoxyphenyl)methyl)malonate (864871-39-6) → 3-amino-3-(4-methoxyphenyl)propionic acid ethyl ester hydrochloride (167887-35-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 85 percent / hydrochloric acid / H₂O / 1 h / Heating

2.1: thionyl chloride / 0.5 h / -10 °C

2.2: 91 percent / ethanol / -10 - 40 °C

With hydrogenchloride; thionyl chloride; In water;

DOI:10.1016/j.tet.2005.04.077

upstream raw materials:

ethanol

3-amino-3-(4-methoxyphenyl)propionic acid

3-amino-3-(4-methoxyphenyl)propanoic acid hydrochloride

diethyl 2-(1-(N-tert-butoxycarbonylamino)-1-(4-methoxyphenyl)methyl)malonate

Refernces

• 1、 Nejman, Micha?,?liwińska, Anna,Zwierzak, Andrzej. "New access to racemic β3-amino acids". . p. 8536 - 8541. Retrieved 2007/10/03.
• 2、 -. "Bispiperidines as antithrombotic agents". . . Retrieved 2008/06/13.