864871-39-6Relevant articles and documents
N-Boc-aminals as easily accessible precursors for less accessible N-Boc-imines: Facile synthesis of optically active propargylamine derivatives using Mannich-type reactions
Yurino, Taiga,Aota, Yusuke,Asakawa, Daisuke,Kano, Taichi,Maruoka, Keiji
, p. 3687 - 3700 (2016)
We developed a facile and practical synthesis of N-Boc-aminals, which can be used as precursors for less accessible N-Boc-imines. Aminals were obtained via simple dehydration condensation reactions of t-butyl carbamate (BocNH2) and various aldehydes in acetic anhydride, followed by filtration and washing with hexane. The obtained N-Boc-alkynylaminals could be successfully applied in enantioselective Mannich-type reactions, catalyzed by chiral phosphoric acids, to afford optically active propargylamine derivatives.
Convenient procedure for synthesis of N-protected β-aminomalonates and β-amino acids from α-amidosulfones
Ananthanawat, Cheeraporn,Banphavichit, Vorawit,Vilaivan, Tirayut
, p. 1845 - 1855 (2007/10/03)
A synthesis of N-protected β-aminomalonates starting from α-amidosulfones under very mild and simple reaction conditions is described. Treatment of the sulfones with malonate esters in the presence of 2.5 equivalents of potassium carbonate affords the des
