N2-(3-aminopropyl)-6,7-dimethoxy-N2-methylquinazoline-2,4-diamine

Base Information

• Chemical Name: N2-(3-aminopropyl)-6,7-dimethoxy-N2-methylquinazoline-2,4-diamine
• CAS No.: 76362-29-3
• Molecular Formula: C14H21N5O2
• Molecular Weight: 291.353
• European Community (EC) Number: 935-448-4
• UNII: X166NKW50I
• Wikidata: Q27293297
• Mol file: 76362-29-3.mol

Synonyms:76362-29-3;N2-(3-aminopropyl)-6,7-dimethoxy-N2-methylquinazoline-2,4-diamine;2,4-Quinazolinediamine, N2-(3-aminopropyl)-6,7-dimethoxy-N2-methyl-;X166NKW50I;N-(4-Amino-6,7-dimethoxyquinazolin-2-yl)-N-methylpropane-1,3-diamine;3-(N-(4-Amino-6,7-dimethoxyquinazolin-2-yl)-N-methylamino)-1-propanamine;UNII-X166NKW50I;Alfuzosin hydrochloride impurity D;Alfuzosin hydrochloride impurity D [EP];SCHEMBL3921653;HVTJQTPDNHTWGI-UHFFFAOYSA-N;AKOS027422459;n1-methyl-n1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-1,3-propanediamine;Q27293297;ALFUZOSIN HYDROCHLORIDE IMPURITY D [EP IMPURITY];N2-(3-aminopropyl)-6,7-dimethoxy-N2-methyl-2,4-quinazolinediamine;2-N-(3-aminopropyl)-6,7-dimethoxy-2-N-methylquinazoline-2,4-diamine;N1-(4-amino-6,7-dimethoxyquinazolin-2-yl)-N1-methylpropane-1,3-diamine

Chemical Property of N2-(3-aminopropyl)-6,7-dimethoxy-N2-methylquinazoline-2,4-diamine

Chemical Property:

• PSA: 99.52000
• LogP: 2.29570
• XLogP3: 1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 6
• Exact Mass: 291.16952493
• Heavy Atom Count: 21
• Complexity: 320

Purity/Quality:

99% ^*data from raw suppliers

N2-(3-AMINOPROPYL)-6,7-DIMETHOXY-N2-METHYLQUINAZOLINE-2,4-DIAMINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(CCCN)C1=NC2=CC(=C(C=C2C(=N1)N)OC)OC

Technology Process of N2-(3-aminopropyl)-6,7-dimethoxy-N2-methylquinazoline-2,4-diamine

There total 6 articles about N2-(3-aminopropyl)-6,7-dimethoxy-N2-methylquinazoline-2,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

3-[(4-amino-6,7-dimethoxy-2-quinazolinyl)methylamino]-propanenitrile (76362-28-2) → N1-methyl-N1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-1,3-propanediamine (76362-29-3)

Guidance literature:

With hydrogen; Rh/Al₂O₃; In methanol; at 45 - 50 ℃; for 6h; under 22067.2 Torr;

Reference yield:

N-(4-amino-6,7-dimethoxyquinazol-2-yl)-N-methyl-2-cyanoethylamine hydrochloride → N1-methyl-N1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-1,3-propanediamine (76362-29-3)

Guidance literature:

With ammonia; hydrogen; Raney nickel; In methanol; at 80 ℃; for 10h; under 7355.72 Torr;

Reference yield:

3-<(4-amino-6,7-dimethoxy-2-quinazolinyl)methylamino>propanenitrile hydrochloride → N1-methyl-N1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-1,3-propanediamine (76362-29-3)

Guidance literature:

With ammonia; hydrogen; nickel; In ethanol; at 70 ℃; under 51714.8 Torr;

DOI:10.1021/jm00151a003

upstream raw materials:

2-chloro-6,7-dimethoxyquinazolin-4-amine

3-[(4-amino-6,7-dimethoxy-2-quinazolinyl)methylamino]-propanenitrile

Downstream raw materials:

alfuzosin

alfuzosin hydrochloride

Refernces

• 1、 -. "Process for the Preparation of Alfuzosin Hydrochloride". Page/Page column 8. . Retrieved 2010/10/19.
• 2、 -. "PROCESS FOR PREPARING ALFUZOSIN". Page/Page column 8-9. . Retrieved 2008/12/07.