Saxagliptin hydrochloride Monohydrate

Base Information

• Chemical Name: Saxagliptin hydrochloride Monohydrate
• CAS No.: 1370409-28-1
• Molecular Formula: C₁₈H₂₅N₃O₂*ClH*2H₂O
• Molecular Weight: 387.907
• Mol file: 1370409-28-1.mol

Synonyms:Saxagliptin hydrochloride Monohydrate;Saxagliptin hydrochloride hydrate

Chemical Property of Saxagliptin hydrochloride Monohydrate

Chemical Property:

• PSA: 99.58000
• LogP: 2.53388

Purity/Quality:

99% ^*data from raw suppliers

SaxagliptinHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Saxagliptin hydrochloride Monohydrate

There total 4 articles about Saxagliptin hydrochloride Monohydrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-cyano-(αS)-α-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)-β-oxo-(1S,3S,5S)-2-azabicyclo[3.1.0]hexane-2-ethanecarbamic acid 1,1-dimethylethyl ester (709031-43-6) → C18H25N3O2*1.33ClH*1.67H2O (1370409-28-1)

Guidance literature:

With hydrogenchloride; In water; ethyl acetate; at 20 - 25 ℃; for 3h;

Reference yield:

saxagliptin monohydrate (945667-22-1) → saxagliptin dihydrochloride dihydrate (1370409-28-1,1073057-20-1)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; ethanol; at 20 ℃;

Reference yield:

saxagliptin dihydrochloride dihydrate (1370409-28-1,1073057-20-1) → C18H25N3O2*ClH*0.75H2O (1370409-28-1)

Guidance literature:

at 50 ℃; for 2h;

upstream raw materials:

saxagliptin monohydrate

(S)-3-hydroxyadamantylglycine-L-cis-4,5-methanoprolinenitrile TFA salt

saxagliptin dihydrochloride dihydrate

3-cyano-(αS)-α-(3-hydroxytricyclo[3.3.1.1^3,7]dec-1-yl)-β-oxo-(1S,3S,5S)-2-azabicyclo[3.1.0]hexane-2-ethanecarbamic acid 1,1-dimethylethyl ester

Refernces