Technology Process of L-GlutaMic acid, N-[4-[1-[(2,4-diaMino-6-pteridinyl)Methyl]-3-butyn-1-yl]benzoyl]-, 1,5-diMethyl ester
There total 10 articles about L-GlutaMic acid, N-[4-[1-[(2,4-diaMino-6-pteridinyl)Methyl]-3-butyn-1-yl]benzoyl]-, 1,5-diMethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
10-propargyl-10-carboxy-4-deoxy-4-amino-10-deazapteroic acid sodium salt;
With
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
N,N-dimethyl acetamide;
at 0 - 5 ℃;
for 0.5h;
Inert atmosphere;
L-glutamic acid dimethyl ester;
With
N-ethyl-N,N-diisopropylamine;
In
N,N-dimethyl acetamide;
at 0 - 25 ℃;
for 21h;
- Guidance literature:
-
With
(benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine;
In
DMF (N,N-dimethyl-formamide);
at 20 - 25 ℃;
for 3h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 °C
1.2: 17 h / 0 - 20 °C
2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 5 °C
2.2: 6 h / -25 - 20 °C
3.1: sodium hydroxide; water / 2-methoxy-ethanol / 4 h / 20 °C
4.1: dimethyl sulfoxide / 0.17 h / 115 - 120 °C
5.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 3 h / 20 - 25 °C
With
water; sodium hydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; sodium hydroxide;
In
tetrahydrofuran; 2-methoxy-ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;
