7-Hydroxy-2-naphthoic acid

Base Information

• Chemical Name: 7-Hydroxy-2-naphthoic acid
• CAS No.: 613-17-2
• Molecular Formula: C11H8O3
• Molecular Weight: 188.183
• Hs Code.: 2918290000
• Mol file: 613-17-2.mol

Synonyms:7-Hydroxy-2-naphthoic acid;7-Hydroxy-2-naphthalenecarboxylic acid

Chemical Property of 7-Hydroxy-2-naphthoic acid

Chemical Property:

• Melting Point: 268-269 °C(Solv: ethanol (64-17-5); water (7732-18-5))
• Boiling Point: 407.0±20.0 °C(Predicted)
• PKA: 4.14±0.30(Predicted)
• PSA: 57.53000
• Density: 1.399±0.06 g/cm3(Predicted)
• LogP: 2.24360
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

≥99.0% ^*data from raw suppliers

7-Hydroxy-2-naphthoicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-Hydroxy-2-naphthoic acid

There total 12 articles about 7-Hydroxy-2-naphthoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

7-benzyloxy-2-naphthoic acid (188904-08-7) → 7-hydroxynaphthalene-2-carboxylic acid (613-17-2)

Guidance literature:

With cyclohexa-1,4-diene; palladium 10% on activated carbon; In ethanol; at 60 ℃; for 24h;

Reference yield:

naphthalene-2-carboxylate (93-09-4) → 8-hydroxy-[2]naphthoic acid (5776-28-3) + 7-hydroxynaphthalene-2-carboxylic acid (613-17-2) + 6-Hydroxy-2-naphthoic acid (16712-64-4)

Guidance literature:

With cytochrome P₄₅₀ enzyme CYP₁₉₉A₄ from Rhodopseudomonas palustris HaA₂; NAD; bovine liver catalase; In ethanol; pH=7.4; Enzymatic reaction;

DOI:10.1002/chem.201202776

Reference yield:

naphthalene-2-carboxylate (93-09-4) → 8-hydroxy-[2]naphthoic acid (5776-28-3) + 7-hydroxynaphthalene-2-carboxylic acid (613-17-2)

Guidance literature:

With oxygen;

DOI:10.1271/bbb.90624

upstream raw materials:

7-methoxy-naphthalen-2-carboxylic acid

7-aminonaphthalene-2-carboxylic acid

7-hydroxynaphthalene-2-carbonitrile

7-sulfo-[2]naphthoic acid

Downstream raw materials:

7-methoxy-naphthalen-2-carboxylic acid

Refernces

• 1、 Bell, Stephen G.,Zhou, Ruimin,Yang, Wen,Tan, Adrian B. H.,Gentleman, Alexander S.,Wong, Luet-Lok,Zhou, Weihong. "Investigation of the substrate range of CYP199A4: Modification of the partition between hydroxylation and desaturation activities by substrate and protein engineering". . p. 16677 - 16688. Retrieved 2013/03/28.
• 2、 -. "AMIDE DERIVATIVES AS SELECTIVE SEROTONIN RE-UPTAKE INHIBITORS". Page 46-47. . Retrieved 2010/02/09.