7-methoxy-2-naphthoic acid

Base Information

• Chemical Name: 7-methoxy-2-naphthoic acid
• CAS No.: 5043-07-2
• Molecular Formula: C12H10O3
• Molecular Weight: 202.20600
• Hs Code.: 2918990090
• Mol file: 5043-07-2.mol

Synonyms:2-Naphthalenecarboxylic acid,7-methoxy;

Chemical Property of 7-methoxy-2-naphthoic acid

Chemical Property:

• PSA: 46.53000
• LogP: 2.54660

Purity/Quality:

95% ^*data from raw suppliers

7-Methoxy-2-naphthoicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-methoxy-2-naphthoic acid

There total 13 articles about 7-methoxy-2-naphthoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

7-methoxynaphthalene-2-carbonitrile (90381-43-4) → 7-methoxy-naphthalen-2-carboxylic acid (5043-07-2)

Guidance literature:

7-methoxynaphthalene-2-carbonitrile; With potassium hydroxide; water; In ethanol; for 24h; Heating / reflux;

With hydrogenchloride; In ethanol; water; pH=< 2;

Reference yield: 98.0%

7-methoxynaphthalene-2-carbonitrile (90381-43-4) → N-[(1S,2R,4R)-7-Azabicyclo[2.2.1]hept-2-yl]-7-methoxy-2-naphthamide hydrochloride (500557-03-9) + 7-methoxy-naphthalen-2-carboxylic acid (5043-07-2)

Guidance literature:

With hydrogenchloride; potassium hydroxide; In ethanol;

Reference yield: 73.0%

carbon dioxide (124-38-9,18923-20-1) + 7-methoxynaphthalen-2-yl pivalate (1122065-27-3) → 7-methoxy-naphthalen-2-carboxylic acid (5043-07-2)

Guidance literature:

With 1,1'-bis-(diphenylphosphino)ferrocene; manganese; [1,1'-bis(diphenylphosphino)ferrocene]nickel(II) chloride; In N,N-dimethyl acetamide; at 80 ℃; for 48h; under 760.051 Torr; Schlenk technique;

DOI:10.1021/ja410883p

upstream raw materials:

7-methoxy-3,4-dihydro-[2]naphthoic acid

7-hydroxynaphthalene-2-carboxylic acid

dimethyl sulfate

7-methoxynaphthalene-2-carboxylic acid ethyl ester

Downstream raw materials:

7-hydroxynaphthalene-2-carboxylic acid

1-(7-methoxy-[2]naphthyl)-ethanone

20(hydroxymethyl)-7-methoxynaphthalene

2-chloromethyl-7-methoxynaphthalene

Refernces

• 1、 Correa, Arkaitz,Leon, Thierry,Martin, Ruben. "Ni-catalyzed carboxylation of C(sp2)- and C(sp3)-O bonds with CO2". supporting information. p. 1062 - 1069. Retrieved 2014/02/14.
• 2、 -. "Substituted-aryl 7-aza[2.2.1]bicycloheptanes for the treatment of disease". . . Retrieved 2008/06/13.