Naphthalene, 2-(chloromethyl)-7-methoxy-

Base Information

• Chemical Name: Naphthalene, 2-(chloromethyl)-7-methoxy-
• CAS No.: 405096-81-3
• Molecular Formula: C₁₂H₁₁ClO
• Molecular Weight: 206.672
• Mol file: 405096-81-3.mol

Synonyms:2-chloromethyl-7-methoxynaphthalene;Naphthalene,2-(chloromethyl)-7-methoxy;

Chemical Property of Naphthalene, 2-(chloromethyl)-7-methoxy-

Chemical Property:

• PSA: 9.23000
• LogP: 3.58720

Purity/Quality:

2-(Chloromethyl)-7-methoxynaphthalene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Naphthalene, 2-(chloromethyl)-7-methoxy-

There total 3 articles about Naphthalene, 2-(chloromethyl)-7-methoxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

20(hydroxymethyl)-7-methoxynaphthalene (5665-20-3) → 2-chloromethyl-7-methoxynaphthalene (405096-81-3)

Guidance literature:

With thionyl chloride; zinc(II) chloride; In 1,4-dioxane; for 0.666667h;

DOI:10.1021/jm00069a006

Reference yield:

7-methoxy-naphthalen-2-carboxylic acid (5043-07-2) → 2-chloromethyl-7-methoxynaphthalene (405096-81-3)

Guidance literature:

Multi-step reaction with 2 steps

1: DIBAL / tetrahydrofuran / 18 h / 0 - 20 °C

2: ZnCl₂, SOCl₂ / dioxane / 0.67 h

With thionyl chloride; diisobutylaluminium hydride; zinc(II) chloride; In tetrahydrofuran; 1,4-dioxane;

DOI:10.1021/jm00069a006

Reference yield:

2-methoxy-7-methylnaphthalene (1131-53-9) → 2-chloromethyl-7-methoxynaphthalene (405096-81-3)

Guidance literature:

With chlorine; triphenylphosphine; In tetrachloromethane;

DOI:10.1016/j.tet.2006.03.082

upstream raw materials:

20(hydroxymethyl)-7-methoxynaphthalene

2-methoxy-7-methylnaphthalene

7-methoxy-naphthalen-2-carboxylic acid

Refernces

• 1、 Ellingboe, John W.,Lombardo, Louis J.,Alessi, Thomas R.,Nguyen, Thomas T.,Guzzo, Frieda,et al.. "Antihyperglycemic Activity of Novel Naphthalenyl 3H-1,2,3,5-Oxathiadiazole 2-Oxides". . p. 2485 - 2493. Retrieved 2007/10/02.