2-Naphthalenemethanol, 7-methoxy-

Base Information

• Chemical Name: 2-Naphthalenemethanol, 7-methoxy-
• CAS No.: 5665-20-3
• Molecular Formula: C12H12O2
• Molecular Weight: 188.22
• European Community (EC) Number: 864-081-1
• Mol file: 5665-20-3.mol

Synonyms:5665-20-3;(7-METHOXYNAPHTHALEN-2-YL)METHANOL;2-Naphthalenemethanol, 7-methoxy-;2-Naphthalenemethanol,7-methoxy-(8CI,9CI);SCHEMBL15118332;AKOS023798709;BS-52313;CS-0199165;E74761;EN300-748933;Z1255505933

Chemical Property of 2-Naphthalenemethanol, 7-methoxy-

Chemical Property:

• Melting Point: 112-114 °C(Solv: benzene (71-43-2); hexane (110-54-3))
• Boiling Point: 358.8±17.0 °C(Predicted)
• PKA: 14.23±0.10(Predicted)
• PSA: 29.46000
• Density: 1.166±0.06 g/cm3(Predicted)
• LogP: 2.34070
• XLogP3: 2.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 188.083729621
• Heavy Atom Count: 14
• Complexity: 181

Purity/Quality:

99%min ^*data from raw suppliers

7-Methoxynaphthalene-2-methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=CC2=C(C=CC(=C2)CO)C=C1

Technology Process of 2-Naphthalenemethanol, 7-methoxy-

There total 4 articles about 2-Naphthalenemethanol, 7-methoxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

7-methoxynaphthalene-2-carboxaldehyde (5665-23-6) → 20(hydroxymethyl)-7-methoxynaphthalene (5665-20-3)

Guidance literature:

With methanol; sodium tetrahydroborate; at 0 - 20 ℃; for 4h; Inert atmosphere;

DOI:10.1002/anie.201806742

Reference yield: 97.0%

7-methoxynaphthalene-2-carboxylic acid ethyl ester (72775-48-5) → 20(hydroxymethyl)-7-methoxynaphthalene (5665-20-3)

Guidance literature:

With lithium aluminium tetrahydride;

Reference yield:

7-methoxy-naphthalen-2-carboxylic acid (5043-07-2) → 20(hydroxymethyl)-7-methoxynaphthalene (5665-20-3)

Guidance literature:

With diisobutylaluminium hydride; In tetrahydrofuran; at 0 - 20 ℃; for 18h;

DOI:10.1021/jm00069a006

upstream raw materials:

7-methoxy-naphthalen-2-carboxylic acid

7-methoxynaphthalene-2-carboxylic acid ethyl ester

2-bromo-7-methoxy-naphthalene

7-methoxynaphthalene-2-carboxaldehyde

Downstream raw materials:

2-ethoxalyl-8-methoxy-1-oxo-2,3-dihydro-1H-cyclopentanaphthalene

2-(carbethoxymethyl)-8-methoxy-1-oxo-2,3-dihydro-1H-cyclopentanaphthalene

2-(carbethoxymethyl)-8-hydroxy-1-oxo-2,3-dihydro-1H-cyclopentanaphthalene

2-(carbamylmethyl)-8-hydroxy-1-oxo-2,3-dihydro-1H-cyclopentanaphthalene

Refernces

• 1、 Ellingboe, John W.,Lombardo, Louis J.,Alessi, Thomas R.,Nguyen, Thomas T.,Guzzo, Frieda,et al.. "Antihyperglycemic Activity of Novel Naphthalenyl 3H-1,2,3,5-Oxathiadiazole 2-Oxides". . p. 2485 - 2493. Retrieved 2007/10/02.