Clodronate disodium

Base Information

• Chemical Name: Clodronate disodium
• CAS No.: 22560-50-5
• Molecular Formula: CCl₂O₆P₂*4Na
• Molecular Weight: 332.82
• Hs Code.: 29319090
• European Community (EC) Number: 245-078-9
• UNII: Y05R4GCQ1H
• DSSTox Substance ID: DTXSID3045225
• Wikidata: Q27126793
• NCI Thesaurus Code: C87474
• RXCUI: 1546871
• ChEMBL ID: CHEMBL1520188
• Mol file: 22560-50-5.mol

Synonyms:Acid, Clodronic;Acid, Dichloromethanediphosphonic;Biphosphonate, Dichloromethylene;Bonefos;Cl2MDP;Clodronate;Clodronate Disodium;Clodronate Sodium;Clodronic Acid;Dichloromethane Diphosphonate;Dichloromethanediphosphonate;Dichloromethanediphosphonic Acid;Dichloromethylene Biphosphonate;Dichloromethylene Diphosphonate;Dichloromethylenebisphosphonate;Diphosphonate, Dichloromethane;Diphosphonate, Dichloromethylene;Disodium, Clodronate;Sodium, Clodronate

Chemical Property of Clodronate disodium

Chemical Property:

• Appearance/Colour: White solid
• Vapor Pressure: 2.55E-10mmHg at 25°C
• Melting Point: >330 °C
• Boiling Point: 474.7oC at 760mmHg
• Flash Point: 240.9oC
• PSA: 140.34000
• Density: 2.306g/cm3
• LogP: 1.30710
• Storage Temp.: -20°C Freezer
• Solubility.: Freely soluble in water, practically insoluble in ethanol (96 per cent), slightly soluble in methanol.
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 2
• Exact Mass: 287.8499057
• Heavy Atom Count: 13
• Complexity: 206

Purity/Quality:

99% ^*data from raw suppliers

ClodronicAcidDisodiumSaltHydrate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C(P(=O)(O)[O-])(P(=O)(O)[O-])(Cl)Cl.[Na+].[Na+]
• Recent ClinicalTrials: S0307 Phase III Trial of Bisphosphonates as Adjuvant Therapy for Primary Breast Cancer.
• Recent EU Clinical Trials: A randomised, double-blind, parallel-group, multicenter, placebo-controlled, dose-ranging study, to evaluate the efficacy and safety of clodronate ampoules at different dosages, after intra-articular administrations to patients affected by knee osteoarthritis
• Description: Clodronate disodium is a bone resorption inhibitor, useful as adjunct therapy in the treatment of osteolytic bone metastases and malignant hypercalcemia.
• Uses: A bisphosphonate antiresorptive agent; bone resorption inhibitor. Clodronic Acid Disodium Salt Hydrate is a bisphosphonate antiresorptive agent; bone resorption inhibitor.
• Clinical Use: Bisphosphonate: Management of osteolytic lesions, hypercalcaemia and bone pain associated with skeletal metastases in patients with breast cancer or multiple myeloma
• Drug interactions: Potentially hazardous interactions with other drugs Cytotoxics: concentration of estramustine increased.