Cyclododecanecarbonitrile

Base Information

• Chemical Name: Cyclododecanecarbonitrile
• CAS No.: 69300-13-6
• Molecular Formula: C13H23N
• Molecular Weight: 193.332
• Mol file: 69300-13-6.mol

Synonyms:Cyclododecanecarbonitrile

Chemical Property of Cyclododecanecarbonitrile

Chemical Property:

• PSA: 23.79000
• LogP: 4.43088

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Cyclododecanecarbonitrile

There total 14 articles about Cyclododecanecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

cyclododecane (294-62-2) + P-toluenesulfonyl cyanide (19158-51-1) → cyclododecanecarbonitrile (69300-13-6)

Guidance literature:

With tetrakis(tetrabutylammonium)decatungstate(VI); In water; acetonitrile; for 3h; Irradiation; Inert atmosphere;

DOI:10.1021/acs.orglett.1c01846

Reference yield: 59.0%

[(p-methylphenyl)sulfonylmethyl]isonitrile (38622-91-2,36635-61-7) + cyclododecanone (830-13-7) → cyclododecanecarbonitrile (69300-13-6)

Guidance literature:

With potassium tert-butylate; In 1,2-dimethoxyethane; tert-butyl alcohol; at 0 ℃; for 24h; Inert atmosphere;

DOI:10.1021/jacs.5b02243

Reference yield: 57.0%

P-toluenesulfonyl cyanide (19158-51-1) + potassium (cyclododecyl)trifluoroborate → cyclododecanecarbonitrile (69300-13-6)

Guidance literature:

With tris(2,2-bipyridine)ruthenium(II) hexafluorophosphate; 1-acetoxy-1,2-benziodoxol-3-one; In dichloromethane; water; at 20 ℃; for 24h; Irradiation;

DOI:10.1039/c6cc01530a

upstream raw materials:

(Z)-Cyclododec-1-enecarbonitrile

potassium cyanide

cyclododecanone (2,4,6-triisopropylbenzenesulfonyl)hydrazone

Cyclododecancarbonsaeureamid

Downstream raw materials:

(E)-cyclododec-1-ene-1-carbonitrile

3-cyclododecylpropanenitrile

3-Cyclododecyl-propionaldehyde

formyl cyclododecane

Refernces

• 1、 -. "Preparation method of alkyl nitrile compound". Paragraph 0249-0254. . Retrieved 2020/05/14.
• 2、 Xia, Aiyou,Xie, Xin,Chen, Haoyi,Zhao, Jidong,Zhang, Chunli,Liu, Yuanhong. "Nickel-Catalyzed Cyanation of Unactivated Alkyl Chlorides or Bromides with Zn(CN)2". supporting information. p. 7735 - 7739. Retrieved 2019/01/03.