(1S)-6,7-dimethoxy-1-[2-(4-trifluoromethyl-phenyl)-ethyl]-1,2,3,4-tetrahydro-isoquinoline hydrochloride

Base Information

• Chemical Name: (1S)-6,7-dimethoxy-1-[2-(4-trifluoromethyl-phenyl)-ethyl]-1,2,3,4-tetrahydro-isoquinoline hydrochloride
• CAS No.: 1296659-30-7
• Molecular Formula: C₂₀H₂₂F₃NO₂*ClH
• Molecular Weight: 401.856
• Mol file: 1296659-30-7.mol

Synonyms:(1S)-6,7-dimethoxy-1-[2-(4-trifluoromethyl-phenyl)-ethyl]-1,2,3,4-tetrahydro-isoquinoline hydrochloride

Chemical Property of (1S)-6,7-dimethoxy-1-[2-(4-trifluoromethyl-phenyl)-ethyl]-1,2,3,4-tetrahydro-isoquinoline hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S)-6,7-dimethoxy-1-[2-(4-trifluoromethyl-phenyl)-ethyl]-1,2,3,4-tetrahydro-isoquinoline hydrochloride

There total 4 articles about (1S)-6,7-dimethoxy-1-[2-(4-trifluoromethyl-phenyl)-ethyl]-1,2,3,4-tetrahydro-isoquinoline hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

6,7-dimethoxy-1-[2-(4-trifluoromethyl-phenyl)-ethyl]-3,4-dihydro-isoquinoline hydrochloride (1169801-38-0) → (1S)-6,7-dimethoxy-1-[2-(4-trifluoromethyl-phenyl)-ethyl]-1,2,3,4-tetrahydro-isoquinoline hydrochloride (1296659-30-7)

Guidance literature:

6,7-dimethoxy-1-[2-(4-trifluoromethyl-phenyl)-ethyl]-3,4-dihydro-isoquinoline hydrochloride; With formic acid; triethylamine; [RhCl₂(p-cymene)]2; (R,R)-N-(p-toluenesulfonyl)-1,2-diphenylethylenediamine; In N,N-dimethyl-formamide; acetonitrile; at 35 ℃; for 3h; Inert atmosphere;

With hydrogenchloride; In ethanol; ethyl acetate;

Reference yield: 59.0%

6,7-dimethoxy-1-[2-(4-trifluoromethyl-phenyl)-ethyl]-3,4-dihydro-isoquinoline hydrochloride (1169801-38-0) → (1S)-6,7-dimethoxy-1-[2-(4-trifluoromethyl-phenyl)-ethyl]-1,2,3,4-tetrahydro-isoquinoline hydrochloride (1296659-30-7) + (1S)-6,7-dimethoxy-1-[2-(4-trifluoromethylphenyl)ethyl]-1,2,3,4-tetrahydroisoquinoline hydrochloride

Guidance literature:

6,7-dimethoxy-1-[2-(4-trifluoromethyl-phenyl)-ethyl]-3,4-dihydro-isoquinoline hydrochloride; With formic acid; triethylamine; [RhCl₂(p-cymene)]2; (R,R)-N-(p-toluenesulfonyl)-1,2-diphenylethylenediamine; In dichloromethane; acetonitrile; for 16h;

With sodium hydrogencarbonate; In dichloromethane; acetonitrile;

With hydrogenchloride; In isopropyl alcohol;

Reference yield:

6,7-dimethoxy-1-[2-(4-trifluoromethyl-phenyl)-ethyl]-3,4-dihydroiso-quinoline (324076-69-9) + formic acid (64-18-6) → (1S)-6,7-dimethoxy-1-[2-(4-trifluoromethyl-phenyl)-ethyl]-1,2,3,4-tetrahydro-isoquinoline hydrochloride (1296659-30-7) + 6,7-dimethoxy-1-[2-(4-trifluoromethyl-phenyl)-ethyl]-3,4-dihydro-1H-isoquinoline-2-carbaldehyde (1260118-25-9)

Guidance literature:

6,7-dimethoxy-1-[2-(4-trifluoromethyl-phenyl)-ethyl]-3,4-dihydroiso-quinoline; formic acid; With triethylamine; [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; (R,R)-N-(p-toluenesulfonyl)-1,2-diphenylethylenediamine; In dichloromethane; acetonitrile; at 20 ℃; for 60h;

With hydrogenchloride; In methanol; isopropyl alcohol; at 40 ℃;

upstream raw materials:

hydrogenchloride

6,7-dimethoxy-1-[2-(4-trifluoromethyl-phenyl)-ethyl]-3,4-dihydroiso-quinoline

formic acid

6,7-dimethoxy-1-[2-(4-trifluoromethyl-phenyl)-ethyl]-3,4-dihydro-isoquinoline hydrochloride

Downstream raw materials:

almorexant hydrochloride

Refernces

• 1、 -. "METHOD FOR THE PREPARATION OF (LS)-6,7-DIMETHOXY-L-[2-(4-TRIFLUOROMETHYLPHENYL)ETHYL]- 1,2,3,4-TETRAHYDROISOQUINOLINE". Page/Page column 12. . Retrieved 2011/05/06.