POLY-L-VALINE

Base Information

• Chemical Name: POLY-L-VALINE
• CAS No.: 25609-85-2
• Molecular Formula: C5H11NO2
• Molecular Weight: 117.14600
• Mol file: 25609-85-2.mol

Synonyms:

Chemical Property of POLY-L-VALINE

Chemical Property:

• Melting Point: 315oC
• PSA: 63.32000
• LogP: 0.75460

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of POLY-L-VALINE

There total 573 articles about POLY-L-VALINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2C16H16O4*C5H11NO2 → L-valine (72-18-4,25609-85-2,7004-03-7,921-10-8) + (S)-2-hydroxy-3-methoxy-3,3-diphenylpropionic acid (178306-52-0,178306-49-5)

Guidance literature:

In ethyl acetate; at 80 ℃; for 3h; Solvent;

Reference yield: 57.4%

L-Glycin (56-40-6,18875-39-3,25718-94-9) + L-Valin-N-carbonsaeureanhydrid (1676-85-3,2816-12-8,24601-74-9,43089-05-0) → L-valine (72-18-4,25609-85-2,7004-03-7,921-10-8) + valylglycine (686-43-1,6491-60-7) + Val-Val (3918-94-3) + N-carbamoylglycine (462-60-2)

Guidance literature:

With water; potassium hydroxide; potassium borate buffer; at 3 ℃; Product distribution; effect of use of various amino acid and NCA with various concentrations; effect of use various temp.; extent of hydrolysis;

Reference yield:

C28H41N5O10 → L-alanin (56-41-7,25191-17-7,18875-37-1) + L-valine (72-18-4,25609-85-2,7004-03-7,921-10-8) + (2R)-aspartic acid (1783-96-6,25608-40-6,27881-03-4,32505-46-7,52526-39-3)

Guidance literature:

With hydrogenchloride; water; at 120 ℃; for 14h;

DOI:10.1021/np2008279

upstream raw materials:

4-isopropylidene-2-thioxo-thiazolidin-5-one

2-chloro-3-methylbutanoic acid

2-bromoisovaleric acid

2-isopropyl-malonamic acid

Downstream raw materials:

D-Valine methyl ester

N-butyrylvaline

(+/-)-N-(2-Thenyl)valin

Glycylvaline

Refernces

• 1、 Shaala, Lamiaa A.,Youssef, Diaa T. A.. "Identification and bioactivity of compounds from the fungus Penicillium sp. CYE-87 isolated from a marine tunicate". . p. 1698 - 1709. Retrieved 2015.
• 2、 Solberg. "Studies on the chemistry of lichens. VII. Chemical investigations of the lichen species Lecanora (Aspicilia) Myrinii (Fr.) Nyl.". . p. 447 - 451. Retrieved 1969.
• 3、 Hiskey et al.. "". . p. 4798. Retrieved 1961.
• 4、 Tsuchida,Yoshinaga,Kubota,Momose. "Production of L valine by 2 thiazolealanine resistant mutants derived from glutamic acid producing bacteria". . p. 1319 - 1322. Retrieved 1975.
• 5、 Bandyopadhyay, Subhajit,Zhou, Wenjun,Breslow, Ronald. "Isotactic polyethylenimines induce formation of L-amino acids in transamination". . p. 1009 - 1012. Retrieved 2007.
• 6、 Huettekeller-Schierlein et al.. "". . p. 1533. Retrieved 1967.
• 7、 SCHIEDT,HOESS. "On the biogenesis of alkaloids. III. Lysine as the precursor to coniine.". . p. 74 - 83. Retrieved 1962.
• 8、 Marma, Mong S.,Kashemirov, Boris A.,McKenna, Charles E.. "Synthesis and stability studies of phosphonoformate-amino acid conjugates: A new class of slowly releasing foscarnet prodrugs". . p. 1787 - 1790. Retrieved 2004.
• 9、 An, Chun-Yan,Li, Xiao-Ming,Li, Chun-Shun,Wang, Ming-Hui,Xu, Gang-Ming,Wang, Bin-Gui. "Aniquinazolines A-D, four new quinazolinone alkaloids from marine-derived endophytic fungus aspergillus nidulans". . p. 2682 - 2694. Retrieved 2013.
• 10、 Cui, Le-Zhi,Lei, Yu,Liao, Xiao-Jian,Wang, Can-Bin,Xiao, Yan-Fang,Xu, Jia-Yi,Xu, Shi-Hai,Zhao, Bing-Xin. "A new amide from the marine sponge Haliclona baeri". . . Retrieved 2021.