3,4'-Dichlorobenzophenone

Base Information

• Chemical Name: 3,4'-Dichlorobenzophenone
• CAS No.: 7498-66-0
• Molecular Formula: C13H8Cl2O
• Molecular Weight: 251.112
• Hs Code.: 2914700090
• Mol file: 7498-66-0.mol

Synonyms:Methanone, (3-chlorophenyl)(4-chlorophenyl)-;Benzophenone,3,4'-dichloro;3,4'-Dichlorbenzophenon;m,p'-dichlorobenzophenone;3,4'-Dichlorobenzophenone;

Chemical Property of 3,4'-Dichlorobenzophenone

Chemical Property:

• Vapor Pressure: 7.7E-06mmHg at 25°C
• Boiling Point: 375.6°Cat760mmHg
• Flash Point: 158.8°C
• PSA: 17.07000
• Density: 1.311g/cm³
• LogP: 4.22440

Purity/Quality:

98% ^*data from raw suppliers

3,4'-Dichlorobenzophenone 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,4'-Dichlorobenzophenone

There total 17 articles about 3,4'-Dichlorobenzophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(E)-2-(3-chlorophenyl)-1-(4-chlorophenyl)ethene (25144-36-9) → (3-chlorophenyl)(4-chlorophenyl)methanone (7498-66-0)

Guidance literature:

With sodium periodate; tetraethylammonium iodide; In water; acetonitrile; at 105 ℃; for 12h; Sealed tube;

DOI:10.1039/c4ra08764j

Reference yield: 63.0%

4-Chlorophenylboronic acid (1679-18-1) + C11H9ClN2 → (3-chlorophenyl)(4-chlorophenyl)methanone (7498-66-0)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium acetate; copper(II) trifluoroacetate; In cyclohexane; at 130 ℃; for 24h; Sealed tube; Inert atmosphere;

DOI:10.1002/ejoc.201800857

Reference yield: 49.0%

1-bromo-3-chlorobenzene (108-37-2) + trimethyl-4-chlorobenzoylsilane (75748-10-6) → (3-chlorophenyl)(4-chlorophenyl)methanone (7498-66-0)

Guidance literature:

With potassium phosphate; PdCl(NH₂C₆H₄C₆H₄)(C₆H₄(CH₃)4O₃PC₆H₅); water; In 2-methyltetrahydrofuran; at 60 ℃; for 20h; Inert atmosphere;

DOI:10.1021/ja2064318

upstream raw materials:

1-(3-chlorophenyl)-1-(4-chlorophenyl)-2,2-dichloroethylene

3-chloro-benzonitrile

(4-chlorphenyl)magnesium bromide

4-chloro-benzoyl chloride

Downstream raw materials:

(3-Chloro-phenyl)-(4-chloro-phenyl)-pyrimidin-5-yl-methanol

3,4'-dichlorobenzhydryl chloride

N-(p-chlorophenyl)-m-chlorobenzamide

2-(3-chloro-phenyl)-2-(4-chloro-phenyl)-[1,3]dioxolane

Refernces

• 1、 -. "NEW CYCLOADDUCT PRECURSORS OF DIHALOBENZOPHENONES AND PREPARATIONS THEREOF". Page/Page column 13-14. . Retrieved 2020/11/30.
• 2、 -. "AZA-PYRIDONE COMPOUNDS AND USES THEREOF". . . Retrieved 2015/03/16.