4-Isopropyl-zimtsaeure-N,N-diethylamid

Base Information

• Chemical Name: 4-Isopropyl-zimtsaeure-N,N-diethylamid
• CAS No.: 42174-82-3
• Molecular Formula: C₁₆H₂₃NO
• Molecular Weight: 245.365
• Mol file: 42174-82-3.mol

Synonyms:4-Isopropyl-zimtsaeure-N,N-diethylamid

Chemical Property of 4-Isopropyl-zimtsaeure-N,N-diethylamid

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Isopropyl-zimtsaeure-N,N-diethylamid

There total 4 articles about 4-Isopropyl-zimtsaeure-N,N-diethylamid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

N-formyldiethylamine (617-84-5) + (E)-4-isopropylcinnamic acid (3368-21-6,116373-36-5) → (E)-N,N-diethyl-3-(4-isopropylphenyl)acrylamide (42174-82-3)

Guidance literature:

With di-tert-butyl peroxide; copper(II) sulfate; at 140 ℃; for 12h; Temperature; Time; Schlenk technique; Inert atmosphere;

DOI:10.1016/j.tet.2013.06.078

Reference yield:

4-isopropylcinnamic acid (3368-21-6) + diethylamine (109-89-7) → 4-Isopropyl-zimtsaeure-N,N-diethylamid (42174-82-3)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 12h; Inert atmosphere;

DOI:10.1016/j.bmcl.2013.01.025

Reference yield:

(E)-4-isopropylcinnamic acid (3368-21-6,116373-36-5) → (E)-N,N-diethyl-3-(4-isopropylphenyl)acrylamide (42174-82-3)

Guidance literature:

With thionyl chloride; Erwaermen des Reaktionsprodukts mit Diaethylamin in Benzol;

DOI:10.1021/ja01165a016

upstream raw materials:

4-isopropylcinnamic acid

diethylamine

(E)-4-isopropylcinnamic acid

N-formyldiethylamine

Refernces

• 1、 Yan, Hong,Yang, Hailong,Lu, Linhua,Liu, Defu,Rong, Guangwei,Mao, Jincheng. "Copper-catalyzed synthesis of α,β-unsaturated acylamides via direct amidation from cinnamic acids and N-substituted formamides". supporting information. p. 7258 - 7263. Retrieved 2013/08/23.