N,N-Diethylformamide

Base Information

• Chemical Name: N,N-Diethylformamide
• CAS No.: 617-84-5
• Molecular Formula: C5H11NO
• Molecular Weight: 101.148
• Hs Code.: 29241990
• European Community (EC) Number: 210-533-2
• NSC Number: 6242
• UNII: D4BLP8BN9H
• DSSTox Substance ID: DTXSID3020463
• Nikkaji Number: J15.779A
• Wikidata: Q4044797
• ChEMBL ID: CHEMBL3186600
• Mol file: 617-84-5.mol

Synonyms:diethylformamide;N,N-diethylformamide

Chemical Property of N,N-Diethylformamide

Chemical Property:

• Appearance/Colour: clear colorless to pale yellow liquid
• Vapor Pressure: 1.04mmHg at 25°C
• Melting Point: 176-177 °C
• Refractive Index: n20/D 1.434(lit.)
• Boiling Point: 177.499 °C at 760 mmHg
• PKA: -0.44±0.70(Predicted)
• Flash Point: 69.109 °C
• PSA: 20.31000
• Density: 0.875 g/cm³
• LogP: 1.12050
• Storage Temp.: Store below +30°C.
• Solubility.: Miscible with acetone, benzene, alcohol and ether.
• XLogP3: 0.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 101.084063974
• Heavy Atom Count: 7
• Complexity: 50

Purity/Quality:

99% ^*data from raw suppliers

N,N-Diethylformamide [for Biochemical Research] >99.0%(GC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39-37/39

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Solvents -> Amides (
• Canonical SMILES: CCN(CC)C=O
• Uses: N,N-Diethylformamide is used in the synthesis of metal-organic frameworks and Diethyltrifluoromethylamine. It is also used as solvent in the preparation of porous cubic-shaped zinc oxide particles. It is involved in the preparation of quinazoline-2,4(1H,3H)-dione by reacting with o-aminonitrile. N,N-Diethylformamide was used in the synthesis of metal-organic frameworks. It was also used as solvent in the synthesis of porous cubic-shaped ZnO particles.

Technology Process of N,N-Diethylformamide

There total 74 articles about N,N-Diethylformamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

carbon dioxide (124-38-9,18923-20-1) + diethylamine (109-89-7) → N-formyldiethylamine (617-84-5)

Guidance literature:

With C₂₁H₂₄N₂; phenylsilane; In tetrahydrofuran; at 20 ℃; for 1.5h; under 750.075 - 2250.23 Torr; Solvent; Concentration; Reagent/catalyst; Temperature; Time; Inert atmosphere; Glovebox;

Reference yield: 98.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + diethylamine (109-89-7) → N-formyldiethylamine (617-84-5)

Guidance literature:

With potassium tetrachloroaurate(III); potassium carbonate; In water; acetonitrile; at 40 ℃; for 12h;

DOI:10.1039/c2cc17689k

Reference yield: 94.0%

N-<(trimethylsilyl)methyl>-N,N-diethylamine (10545-36-5) → N-formyldiethylamine (617-84-5)

Guidance literature:

With copper(I) bromide; In acetonitrile; at 25 ℃; for 4h; chemoselective reaction;

DOI:10.1039/d0gc01242d

upstream raw materials:

chloral

diethylamine

formic acid

diethyl ether

Downstream raw materials:

diethyl-(β-phenoxy-isopropyl)-amine

cyclohexanecarbaldehyde

butyraldehyde

phenylacetaldehyde

Refernces

• 1、 -. "Method for preparing formamide compound by using MCOF to catalyze CO2 as carbon source at normal temperature and pressure". Paragraph 0034. . Retrieved 2021/06/09.
• 2、 Shen, Yajing,Zheng, Qingshu,Chen, Zhe-Ning,Wen, Daheng,Clark, James H.,Xu, Xin,Tu, Tao. "Highly Efficient and Selective N-Formylation of Amines with CO2 and H2 Catalyzed by Porous Organometallic Polymers". supporting information. p. 4125 - 4132. Retrieved 2021/01/12.