Technology Process of Trichodiene
There total 18 articles about Trichodiene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
Tris buffer pH 7.8; 2-hydroxyethanethiol; magnesium chloride;
at 30 ℃;
for 16h;
Further byproducts given. Title compound not separated from byproducts;
D98E mutant of recombinant F. sporotrichioides trichodiene synthase;
DOI:10.1021/ja961897w
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) LDA
2: LiAlH4 / diethyl ether / 12 h / 25 °C
3: 1.) n-BuLi, N,N,N',N'-tetramethylethylenediamine / 1.) dimethoxyethane, hexane, 0 deg C, 5 min, 2.) dimethoxyethane, hexane, RT, 1 h
4: Li, t-BuOH, ethylamine / 2 h / 0 °C
With
lithium aluminium tetrahydride; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; lithium; ethylamine; tert-butyl alcohol; lithium diisopropyl amide;
In
diethyl ether;
DOI:10.1021/jo00373a032
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 81 percent / pyridine / 12 h / Ambient temperature
2: 1.) LDA
3: LiAlH4 / diethyl ether / 12 h / 25 °C
4: 1.) n-BuLi, N,N,N',N'-tetramethylethylenediamine / 1.) dimethoxyethane, hexane, 0 deg C, 5 min, 2.) dimethoxyethane, hexane, RT, 1 h
5: Li, t-BuOH, ethylamine / 2 h / 0 °C
With
pyridine; lithium aluminium tetrahydride; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; lithium; ethylamine; tert-butyl alcohol; lithium diisopropyl amide;
In
diethyl ether;
DOI:10.1021/jo00373a032
