8-hydroxydesmethylmianserin

Base Information

• Chemical Name: 8-hydroxydesmethylmianserin
• CAS No.: 77117-73-8
• Molecular Formula: C₁₇H₁₈N₂O
• Molecular Weight: 266.343
• Hs Code.: 2933990090
• Mol file: 77117-73-8.mol

Synonyms:8-hydroxydesmethylmianserin

Chemical Property of 8-hydroxydesmethylmianserin

Chemical Property:

• Vapor Pressure: 3.69E-11mmHg at 25°C
• Boiling Point: 513.4°C at 760 mmHg
• Flash Point: 264.3°C
• PSA: 35.50000
• Density: 1.29g/cm³
• LogP: 2.84110

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 8-hydroxydesmethylmianserin

There total 3 articles about 8-hydroxydesmethylmianserin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

mianserin (24219-97-4) → 8-Hydroxy-N-Desmethylmianserin (77117-73-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 62 percent / bromine / acetic acid / 4 h / Ambient temperature

2: 1) BuLi, 2) nitrobenzene / 1) THF, hexane, -60 deg C, 45 min, 2) THF, hexane, -196 to -60 deg C and 3.5 h at -60 deg C

3: 1) ClCOOEt, 2) 48percent aq. HBr / 1) toluene, reflux, 2 h, 2) 5 h, reflux

With n-butyllithium; hydrogen bromide; bromine; chloroformic acid ethyl ester; nitrobenzene; In acetic acid;

DOI:10.1002/recl.19851041004

Reference yield:

8-Hydroxymianserin (57257-81-5) → 8-Hydroxy-N-Desmethylmianserin (77117-73-8)

Guidance literature:

With hydrogen bromide; chloroformic acid ethyl ester; Yield given. Multistep reaction; 1) toluene, reflux, 2 h, 2) 5 h, reflux;

DOI:10.1002/recl.19851041004

Reference yield:

8-bromomianserin (57257-87-1) → 8-Hydroxy-N-Desmethylmianserin (77117-73-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) BuLi, 2) nitrobenzene / 1) THF, hexane, -60 deg C, 45 min, 2) THF, hexane, -196 to -60 deg C and 3.5 h at -60 deg C

2: 1) ClCOOEt, 2) 48percent aq. HBr / 1) toluene, reflux, 2 h, 2) 5 h, reflux

With n-butyllithium; hydrogen bromide; chloroformic acid ethyl ester; nitrobenzene;

DOI:10.1002/recl.19851041004

upstream raw materials:

8-Hydroxymianserin

8-bromomianserin

mianserin

Refernces