Mianserin

Base Information

• Chemical Name: Mianserin
• CAS No.: 24219-97-4
• Molecular Formula: C18H20 N2
• Molecular Weight: 264.37
• Hs Code.: 2933990090
• European Community (EC) Number: 246-088-6
• UNII: 250PJI13LM
• DSSTox Substance ID: DTXSID6023317
• Nikkaji Number: J16.389I
• Wikipedia: Mianserin
• Wikidata: Q416701
• NCI Thesaurus Code: C87209
• Pharos Ligand ID: X2LWM2TXM46X
• Metabolomics Workbench ID: 43659
• ChEMBL ID: CHEMBL6437
• Mol file: 24219-97-4.mol

Synonyms:Hydrochloride, Mianserin;Lerivon;Mianserin;Mianserin Hydrochloride;Mianserin Monohydrochloride;Monohydrochloride, Mianserin;Org GB 94;Tolvon

Chemical Property of Mianserin

Chemical Property:

• Refractive Index: 1.5200 (estimate)
• Boiling Point: 411.3°Cat760mmHg
• PKA: pKa 7.5(H2O,t =20.0) (Uncertain)
• Flash Point: 186.1°C
• PSA: 6.48000
• Density: 1.18g/cm³
• LogP: 3.08680
• XLogP3: 3.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 264.162648646
• Heavy Atom Count: 20
• Complexity: 342

Purity/Quality:

98%,99%, ^*data from raw suppliers

Mianserin ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1CCN2C(C1)C3=CC=CC=C3CC4=CC=CC=C42
• Recent ClinicalTrials: A Study of Mianserin in Combination With SSRIs in Depression With Sleep Problems
• Recent EU Clinical Trials: TREATMENT OF SLEEP DISTURBANCES IN TRAUMA-AFFECTED REFUGEES – A RANDOMISED CONTROLLED TRIAL
• Recent NIPH Clinical Trials: Pharmacokinetics of mianserin suppository in Japanese elderly healthy volunteers -a pilot study
• Uses: Serotonin receptor antagonist. Antidepressant
• Therapeutic Function: Serotonin antagonist, Antihistaminic

Technology Process of Mianserin

There total 24 articles about Mianserin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

3,4-dioxomianserin (21535-46-6) → mianserin (24219-97-4)

Guidance literature:

With sodium tetrahydroborate; boron trifluoride diethyl etherate; In tetrahydrofuran; 1) 25 degC, 2 h, 2) reflux, 2 h;

Reference yield: 80.0%

2-(4-methyl-2-phenylpiperazin-1-yl)-pyridine-3-methanol (61337-89-1) → mianserin (24219-97-4)

Guidance literature:

2-(4-methyl-2-phenylpiperazin-1-yl)-pyridine-3-methanol; With sulfuric acid; at 30 - 40 ℃; Inert atmosphere;

With sodium hydroxide; In water; isopropyl alcohol; at 13 - 33 ℃; pH=1.5 - 11.2; Product distribution / selectivity;

Reference yield:

1,2,3,4,10,14b-hexahydrodibenzo[c,f]-pyrazino[1,2-a]azepine (71936-92-0,136315-25-8) + methyl iodide (74-88-4) → mianserin (24219-97-4)

Guidance literature:

With potassium carbonate; In tetrahydrofuran; at 24 - 25 ℃;

DOI:10.3762/bjoc.11.164

upstream raw materials:

3,4-dioxomianserin

4,7-bis(2-carboxyethyl)decanedioic acid

2-(3,4-dimethoxyphenyl)-ethylamine

2-(4-methyl-2-phenylpiperazin-1-yl)-pyridine-3-methanol

Downstream raw materials:

1,2,3,4,10,14b-hexahydrodibenzo[c,f]-pyrazino[1,2-a]azepine

mianserin

8-Hydroxy-N-Desmethylmianserin

8-Hydroxymianserin

Refernces

• 1、 Roszkowski, Piotr,Maurin,Czarnocki, Zbigniew. "The enantioselective synthesis of (S)-(+)-mianserin and (S)-(+)-epinastine". . p. 1509 - 1513. Retrieved 2016/04/09.
• 2、 Hulinska, Hana,Polivka, Zdenek,Jilek, Jiri,Sindelar, Karel,Holubek, Jiri,et al.. "EXPERIMENTAL ANTIULCER AGENTS: N-SUBSTITUTED 2-(4-METHYL-1-PIPERAZINYL)ACETAMIDES AS PIRENZEPINE MODELS AND SOME RELATED COMPOUNDS". . p. 1820 - 1844. Retrieved 2007/10/02.