61337-89-1

Basic information

• Product Name: 1-(3-Hydroxymethylpyridin-2-yl)-4-methyl-2-phenylpiperazine
• Synonyms: [2-(4-METHYL-2-PHENYLPIPERAZIN-1-YL)PYRIDIN-3-YL]METHANOL;2-(4-METHYL-2-PHENYL-1-PIPERAZINYL)-3-PYRIDINEMETHANOL;1-(3-HYDROXYMETHYL PYRIDIN-2-YL)-4-METHYL-2-PHENYL PIPERAZINE;1-(3-HYDROXYMETHYLPYRIDINE)-2-PHENYL-4-METHYL-PIPERAZINE;1-(3-HYDROXIDMETHYLPYRIDINE)-2-PHENYL-4-METHYL-PIPERAZINE;1-(3-Hydroxymethylpyridyl-2)-2-Phenyl-4-Methylpyperazine;1-(3-Hydroxymethylpyridin-2-Yl;2-(4-methyl-2-phenyl-1-piperazinyl)-3-pyridinemethanol (intermediate of mirtazapine)
• CAS NO: 61337-89-1
• Molecular Formula: C17H21N3O
• Molecular Weight: 283.37
• EINECS: 1308068-626-2
• Product Categories: Alkohols;Organic acids;Piperazine derivates;(intermediate of mirtazapine);(intermediate of azelastine hcl);l(intermediate of mirtazapine);Aromatics;Heterocycles;Miscellaneous Reagents;Intermediate Mirtazapine
• Mol File: 61337-89-1.mol
• Article Data: 19

Chemical Properties

• Melting Point: 113-115°C
• Boiling Point: 478.753 °C at 760 mmHg
• Flash Point: 243.341 °C
• Appearance: White solid
• Density: 1.161 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.602
• Storage Temp.: -20°C Freezer, Under Inert Atmosphere
• Solubility: DMSO (Sparingly), Methanol (Slightly)
• PKA: 13.59±0.10(Predicted)
• CAS DataBase Reference: 1-(3-Hydroxymethylpyridin-2-yl)-4-methyl-2-phenylpiperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-Hydroxymethylpyridin-2-yl)-4-methyl-2-phenylpiperazine(61337-89-1)
• EPA Substance Registry System: 1-(3-Hydroxymethylpyridin-2-yl)-4-methyl-2-phenylpiperazine(61337-89-1)

Safety Data

• Hazardous Substances Data: 61337-89-1(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

Different sources of media describe the Uses of 61337-89-1 differently. You can refer to the following data:
1. An impurity found in Mirtazapine (M365000). Mirtazapine Impurity B.
2. 2-(4-Methyl-2-phenyl-1-piperazinyl)-3-pyridinemethanol is an impurity found in Mirtazapine (M365000). Mirtazapine Impurity B.

InChI:InChI=1/C17H21N3O/c1-19-10-11-20(17-15(13-21)8-5-9-18-17)16(12-19)14-6-3-2-4-7-14/h2-9,16,21H,10-13H2,1H3

Upstream product

• 61338-13-4 2-(4-methyl-2-phenyl-1-piperazinyl)-3-pyridinecarboxylic acid 
• 10366-35-5 2-chloronicotinamide 
• 13362-26-0 2-aminopyridine-3-carboxylic acid ethyl ester 
• 61337-88-0 3-cyano-2-(4-methyl-2-phenyl-1-piperazynyl)pyridine 
• 5271-27-2 1-methyl-3-phenylpiperazine 
• 6602-54-6 2-chloro-3-pyridinecarbonitrile 

Downstream Products

• 85650-52-8 Mirtazapine 
• 24219-97-4 mianserin 

Relevant articles and documents

A rice the nitrogen is mellow synthetic method

The invention discloses a 1-(3-hydroxymethylpyridine-2-yl)-4-methyl-2-phenylpiperazine synthesis method. The method includes: dissolving N-(2-chloroethyl)-N-methyl-alpha-chlorine-beta phenethylamine in mixed solution of water and a nonpolar solvent to obtain solution A, and dissolving 2-amino-3-hydroxymethylpyridine into a nonpolar solvent containing a small quantity of low carbon alcohols to obtain solution B; dripping the solution B into the solution A to obtain an intermediate by reaction, dissolving the intermediate into an anhydrous high-boiling-point polar solvent, and dripping into an anhydrous high-boiling-point polar solvent of inorganic iodides under inert gas shielding to realize reaction for obtaining 1-(3-hydroxymethylpyridine-2-yl)-4-methyl-2-phenylpiperazine. By two steps for synthesis of 1-(3-hydroxymethylpyridine-2-yl)-4-methyl-2-phenylpiperazine, oxidization of the intermediate due to direct high-temperature reaction can be avoided by specific solvent systems, and reaction stability and yield are improved.

MANUFACTURING METHOD OF MIRTAZAPINE

PROBLEM TO BE SOLVED: To provide a method for manufacturing mirtazapine useful as an antidepressant at high quality and high manufacturing yield. SOLUTION: Mirtazapine with reduced impurities is manufactured by crystallizing mirtazapine by using a mixed solvent of a good solvent selected from an alcohol solvent, a ketone solvent, an ether solvent and an ester solvent and a poor solvent selected from heptane and hexane, or a mixed solvent of a good solvent and a poor solvent in which a good solvent which is acetonitrile and a poor solvent which is water in a method of manufacturing mirtazapine by reacting 2-(4-methyl-2-phenyl-1-piperazinyl)-3-pyridinemethanol and sulfuric acid. SELECTED DRAWING: None COPYRIGHT: (C)2017,JPOandINPIT

METHOD FOR PRODUCING MIRTAZAPINE

PROBLEM TO BE SOLVED: To provide a method in which mirtazapine useful as an antidepressant can be produced at high quality as well as at high production yield. SOLUTION: In a method for producing mirtazapine by reacting 2-(4-methyl-2-phenylpiperazin-1-yl)-3-pyridinemethanol with sulfuric acid, when an alcohol solution of crude mirtazapine obtained as a concentrated residue of a toluene extraction liquid is subjected to activated carbon treatment, the amount of toluene is made 15 g or less with respect to 100 g of the alcohol solution, whereby the reduction efficiency of specific impurities during the activated carbon treatment can be improved, and as a result, mirtazapine with high quality can be produced. SELECTED DRAWING: None COPYRIGHT: (C)2017,JPOandINPIT