3-Cyano-4-azahomoadamantane

Base Information

• Chemical Name: 3-Cyano-4-azahomoadamantane
• CAS No.: 78837-35-1
• Molecular Formula: C₁₁H₁₆N₂
• Molecular Weight: 176.261
• Mol file: 78837-35-1.mol

Synonyms:3-Cyano-4-azahomoadamantane

Chemical Property of 3-Cyano-4-azahomoadamantane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Cyano-4-azahomoadamantane

There total 3 articles about 3-Cyano-4-azahomoadamantane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

1-Azidoadamantane (24886-73-5) + sodium cyanide (143-33-9,25596-52-5) → 6-hydroxy-5-azatricyclo<4.3.1.13,8>undecane (55086-02-7) + 3-Cyano-4-azahomoadamantane (78837-35-1)

Guidance literature:

With adogen 464; In hexane; water; for 3h; Ambient temperature; Irradiation;

DOI:10.1021/jo00335a030

Reference yield: 57.0%

1-Azidoadamantane (24886-73-5) + potassium cyanide (151-50-8) → 6-hydroxy-5-azatricyclo<4.3.1.13,8>undecane (55086-02-7) + 3-Cyano-4-azahomoadamantane (78837-35-1)

Guidance literature:

With 18-crown-6 ether; In tetrahydrofuran; tert-butyl alcohol; for 22h; Ambient temperature; Irradiation;

DOI:10.1021/jo00335a030

Reference yield: 51.0%

trimethylsilyl cyanide (7677-24-9) + 1-Azidoadamantane (24886-73-5) → 6-hydroxy-5-azatricyclo<4.3.1.13,8>undecane (55086-02-7) + 3-Cyano-4-azahomoadamantane (78837-35-1)

Guidance literature:

With aluminium trichloride; In tetrachloromethane; for 18h; Heating;

DOI:10.1021/jo00335a030

upstream raw materials:

trimethylsilyl cyanide

1-Azidoadamantane

sodium cyanide

potassium cyanide

Downstream raw materials:

4-Oxo-5-phenyl-5,7-diazatetracyclo<7.3.1.1^3,11.0^3,7>tetradecan-6-thione

5-Phenyl-5,7-diazatetracyclo<7.3.1.1^3,11.0^3,7>tetradecan-4,6-dione

4-Imino-5-phenyl-5,7-diazatetracyclo<7.3.1.1^3,11.0^3,7>tetradecan-6-thione

4-Imino-5-phenyl-5,7-diazatetracyclo<7.3.1.1^3,11.0^3,7>tetradecan-6-one

Refernces