1-(p-methylphenyl)-1-cyanoacetone

Base Information

• Chemical Name: 1-(p-methylphenyl)-1-cyanoacetone
• CAS No.: 27243-91-0
• Molecular Formula: C₁₁H₁₁NO
• Molecular Weight: 173.214
• Mol file: 27243-91-0.mol

Synonyms:1-(p-methylphenyl)-1-cyanoacetone

Chemical Property of 1-(p-methylphenyl)-1-cyanoacetone

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(p-methylphenyl)-1-cyanoacetone

There total 2 articles about 1-(p-methylphenyl)-1-cyanoacetone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(4-methylphenyl)acetonitrile (2947-61-7) + ethyl acetate (141-78-6) → 1-(p-methylphenyl)-1-cyanoacetone (27243-91-0)

Guidance literature:

(4-methylphenyl)acetonitrile; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 1h; Inert atmosphere; Cooling with ice;

ethyl acetate; In tetrahydrofuran; at 60 ℃; Inert atmosphere;

DOI:10.1002/anie.202007520

Reference yield:

(4-methylphenyl)acetonitrile (2947-61-7) → 1-(p-methylphenyl)-1-cyanoacetone (27243-91-0)

Guidance literature:

With sodium ethanolate; ethyl acetate;

Reference yield: 92.0%

boron trifluoride diethyl etherate (109-63-7) + 1-(p-methylphenyl)-1-cyanoacetone (27243-91-0) + water (7732-18-5) → 2,2-difluoro-6-methyl-5-(4-methylphenyl)-2H-1,3λ3,2λ4-dioxaborinin-4-amine

Guidance literature:

In 5,5-dimethyl-1,3-cyclohexadiene; for 20h; Reflux;

DOI:10.1039/c7ob01356f

upstream raw materials:

(4-methylphenyl)acetonitrile

ethyl acetate

Downstream raw materials:

6-methyl-5-p-tolyl-pyrimidine-2,4-diamine

p-Tolylaceton

4-methyl methamphetamine

trans-3-(methoxyimino)-2-(p-tolyl)butanenitrile

Refernces

• 1、 Pippione, Agnese C.,Sainas, Stefano,Federico, Antonella,Lupino, Elisa,Piccinini, Marco,Kubbutat, Michael,Contreras, Jean-Marie,Morice, Christophe,Barge, Alessandro,Ducime, Alex,Boschi, Donatella,Al-Karadaghi, Salam,Lolli, Marco L.. "N -Acetyl-3-aminopyrazoles block the non-canonical NF-kB cascade by selectively inhibiting NIK". supporting information. p. 963 - 968. Retrieved 2018/06/27.