2-acetoxy-4-chloro-1-methoxybenzene

Base Information

• Chemical Name: 2-acetoxy-4-chloro-1-methoxybenzene
• CAS No.: 66037-03-4
• Molecular Formula: C₉H₉ClO₃
• Molecular Weight: 200.622
• Mol file: 66037-03-4.mol

Synonyms:2-acetoxy-4-chloro-1-methoxybenzene

Chemical Property of 2-acetoxy-4-chloro-1-methoxybenzene

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-acetoxy-4-chloro-1-methoxybenzene

There total 3 articles about 2-acetoxy-4-chloro-1-methoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

2-methoxyphenyl acetate (613-70-7) → 2-acetoxy-4-chloro-1-methoxybenzene (66037-03-4)

Guidance literature:

With N-chloro-succinimide; In acetonitrile; at 20 ℃; for 336h;

DOI:10.1039/b506735a

Reference yield: 41.0%

4-chloromethoxybenzene (623-12-1) + acetic acid (64-19-7,77671-22-8) → 2-acetoxy-4-chloro-1-methoxybenzene (66037-03-4)

Guidance literature:

With sodium nitrate; acetic anhydride; trifluoroacetic acid; at 50 ℃; for 14h; regioselective reaction; Inert atmosphere;

DOI:10.1021/acs.orglett.1c02183

Reference yield:

5-chloro-2-methoxyphenol (3743-23-5) + acetic anhydride (108-24-7) → 2-acetoxy-4-chloro-1-methoxybenzene (66037-03-4)

Guidance literature:

With sodium acetate;

DOI:10.1345/aph.10120

upstream raw materials:

5-chloro-2-methoxyphenol

acetic anhydride

2-methoxyphenyl acetate

4-chloromethoxybenzene

Downstream raw materials:

chavibetol

6-chloroacetoguaiacone

4-chloroguaiacol acetate

Refernces

• 1、 Protti, Stefano,Fagnoni, Maurizio,Albini, Angelo. "Expeditious synthesis of bioactive allylphenol constituents of the genus Piper through a metal-free photoallylation procedure". . p. 2868 - 2871. Retrieved 2007/10/03.