2-(4-methoxyphenyl)-5-pentylthiophene

Base Information

• Chemical Name: 2-(4-methoxyphenyl)-5-pentylthiophene
• CAS No.: 301199-35-9
• Molecular Formula: C₁₆H₂₀OS
• Molecular Weight: 260.4
• Mol file: 301199-35-9.mol

Synonyms:2-(4-methoxyphenyl)-5-pentylthiophene

Chemical Property of 2-(4-methoxyphenyl)-5-pentylthiophene

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

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Technology Process of 2-(4-methoxyphenyl)-5-pentylthiophene

There total 4 articles about 2-(4-methoxyphenyl)-5-pentylthiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

2-pentyl-thiophene (4861-58-9) + 1-bromo-4-methoxy-benzene (104-92-7) → 2-(4-methoxyphenyl)-5-pentylthiophene (301199-35-9)

Guidance literature:

With palladium 10% on activated carbon; potassium acetate; In N,N-dimethyl acetamide; at 150 ℃; for 16h; Inert atmosphere;

DOI:10.1002/adsc.201800596

Reference yield:

4-methoxyphenylboronic acid (5720-07-0) + sodium carbonate (497-19-8) + 2-bromo-5-pentylthiophene (301199-32-6) → 2-(4-methoxyphenyl)-5-pentylthiophene (301199-35-9)

Guidance literature:

With hydrogenchloride; tetrakis(triphenylphosphine)palladium ⁽⁰⁾; In 1,2-dimethoxyethane; hexane; dichloromethane;

Reference yield:

2-pentyl-thiophene (4861-58-9) → 2-(4-methoxyphenyl)-5-pentylthiophene (301199-35-9)

Guidance literature:

Multi-step reaction with 2 steps

1: NBS; acetic acid / CHCl₃

2: Na₂CO₃ / Pd(PPh₃)4 / 1,2-dimethoxy-ethane; H₂O

With N-Bromosuccinimide; sodium carbonate; acetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; chloroform; water; 2: Suzuki coupling;

DOI:10.1080/10587250108025061

upstream raw materials:

4-methoxyphenylboronic acid

2-bromo-5-pentylthiophene

2-pentyl-thiophene

sodium carbonate

Downstream raw materials:

2-(4-hydroxyphenyl)-5-pentylthiophene

Refernces

• 1、 -. "Liquid crystalline alkenyl compounds incorporating an heterocyclic five-membered ring". . . Retrieved 2008/06/13.
• 2、 Bartle, Kevin,Campbell, Neil,Duffy, Warren L.,Kelly, Stephen M.,Minter, Vicki,O'Neill, Mary,Tuffin, Rachel P.. "Nematic thiophenes for STN-LCDS and flexoelectric LCDS". . p. 881 - 888. Retrieved 2007/10/03.