8-(phenylmethoxy)-5-[(R)-2-(5,6-diethyl-indan-2-ylamino)-1-hydroxy-ethyl]-(1H)-quinolin-2-one tartrate

Base Information

• Chemical Name: 8-(phenylmethoxy)-5-[(R)-2-(5,6-diethyl-indan-2-ylamino)-1-hydroxy-ethyl]-(1H)-quinolin-2-one tartrate
• CAS No.: 753498-33-8
• Molecular Formula: C₄H₆O₆*C₃₁H₃₄N₂O₃
• Molecular Weight: 632.711
• Mol file: 753498-33-8.mol

Synonyms:8-(phenylmethoxy)-5-[(R)-2-(5,6-diethyl-indan-2-ylamino)-1-hydroxy-ethyl]-(1H)-quinolin-2-one tartrate

Chemical Property of 8-(phenylmethoxy)-5-[(R)-2-(5,6-diethyl-indan-2-ylamino)-1-hydroxy-ethyl]-(1H)-quinolin-2-one tartrate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 8-(phenylmethoxy)-5-[(R)-2-(5,6-diethyl-indan-2-ylamino)-1-hydroxy-ethyl]-(1H)-quinolin-2-one tartrate

There total 2 articles about 8-(phenylmethoxy)-5-[(R)-2-(5,6-diethyl-indan-2-ylamino)-1-hydroxy-ethyl]-(1H)-quinolin-2-one tartrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

8-(benzyloxy)-5-[(1R)-2-bromo-1-hydroxyethyl]quinolin-2(1H)-one (530084-79-8) + 5,6-diethyl-2,3-dihydro-1H-inden-2-amine (312753-70-1) + L-Tartaric acid (87-69-4,138508-61-9) → 8-(phenylmethoxy)-5-[(R)-2-(5,6-diethyl-indan-2-ylamino)-1-hydroxy-ethyl]-(1H)-quinolin-2-one tartrate (753498-33-8)

Guidance literature:

8-(benzyloxy)-5-[(1R)-2-bromo-1-hydroxyethyl]quinolin-2(1H)-one; With -butyl vinyl ether; toluene-4-sulfonic acid; In tetrahydrofuran; toluene; at 20 - 25 ℃; for 0.5h; Molecular sieve;

5,6-diethyl-2,3-dihydro-1H-inden-2-amine; With N-ethyl-N,N-diisopropylamine; sodium iodide; In N,N-dimethyl-formamide; at 100 ℃;

L-Tartaric acid; Further stages;

Reference yield:

(R)-8-(benzyloxy)-5-[2-[(5,6-diethyl-2,3-dihydro-1H-indole-2-yl)amino]-1-hydroxyethyl]quinolin-2(1H)-one (435273-75-9) + L-Tartaric acid (87-69-4,138508-61-9) → 8-(phenylmethoxy)-5-[(R)-2-(5,6-diethyl-indan-2-ylamino)-1-hydroxy-ethyl]-(1H)-quinolin-2-one tartrate (753498-33-8)

Guidance literature:

In ethanol; water; for 0.5h; Reflux;

Reference yield: 79.0%

8-(phenylmethoxy)-5-[(R)-2-(5,6-diethyl-indan-2-ylamino)-1-hydroxy-ethyl]-(1H)-quinolin-2-one tartrate (753498-33-8) + maleic acid (110-16-7,26099-09-2) → indacaterol maleate (753498-25-8)

Guidance literature:

8-(phenylmethoxy)-5-[(R)-2-(5,6-diethyl-indan-2-ylamino)-1-hydroxy-ethyl]-(1H)-quinolin-2-one tartrate; With 5%-palladium/activated carbon; hydrogen; In methanol; under 225.023 Torr; Inert atmosphere;

maleic acid; In isopropyl alcohol; at 70 - 80 ℃; for 0.5h;

upstream raw materials:

8-(benzyloxy)-5-[(1R)-2-bromo-1-hydroxyethyl]quinolin-2(1H)-one

5,6-diethyl-2,3-dihydro-1H-inden-2-amine

L-Tartaric acid

(R)-8-(benzyloxy)-5-[2-[(5,6-diethyl-2,3-dihydro-1H-indole-2-yl)amino]-1-hydroxyethyl]quinolin-2(1H)-one

Downstream raw materials:

indacaterol

indacaterol maleate

Refernces

• 1、 -. "METHODS FOR THE PREPARATION OF INDACATEROL AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF". Page/Page column 19. . Retrieved 2014/04/04.