2-Naphthyl acetate

Base Information

• Chemical Name: 2-Naphthyl acetate
• CAS No.: 1523-11-1
• Molecular Formula: C12H10O2
• Molecular Weight: 186.21
• Hs Code.: 2915390090
• European Community (EC) Number: 216-194-7
• NSC Number: 37069
• DSSTox Substance ID: DTXSID60883578
• Nikkaji Number: J7.509D
• Wikidata: Q63399287
• Mol file: 1523-11-1.mol

Synonyms:2-Naphthyl acetate;1523-11-1;naphthalen-2-yl acetate;2-Acetoxynaphthalene;2-Naphthalenol, acetate;2-Naphthol, acetate;beta-Naphthyl acetate;2-Naphthalenol, 2-acetate;Naphthalene, 2-acetoxy-;beta-Naphthol acetate;O-Acetyl-beta-naphthol;.beta.-Naphthol acetate;.beta.-Naphthyl acetate;NSC 37069;O-Acetyl-.beta.-naphthol;EINECS 216-194-7;AI3-17247;2-NAPHTHYLACETATE;ss-Naphthyl Acetate;MFCD00004060;naphthalen-2-ylacetate;Acetic acid 2-naphthyl;Acetic Acid 2-Naphthyl Ester;SCHEMBL338523;DTXSID60883578;acetic acid naphthalen-2-yl ester;Acetic acid .beta.-naphthyl ester;NSC37069;NSC-37069;AKOS015899138;2-Naphthyl acetate, esterase substrate;FD10475;AS-57010;HY-131927;A0038;CS-0143622;FT-0613139;A19455;J-510148;Q63399287

Chemical Property of 2-Naphthyl acetate

Chemical Property:

• Appearance/Colour: White fluffy powder
• Vapor Pressure: 0.000618mmHg at 25°C
• Melting Point: 67-70 °C(lit.)
• Refractive Index: 1.603
• Boiling Point: 309.978 °C at 760 mmHg
• Flash Point: 110.402 °C
• PSA: 26.30000
• Density: 1.155 g/cm³
• LogP: 2.76510
• Storage Temp.: −20°C
• Sensitive.: Moisture Sensitive
• Solubility.: methanol: 0.1 g/mL, clear
• XLogP3: 2.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 186.068079557
• Heavy Atom Count: 14
• Complexity: 212

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Naphthyl Acetate >98.0%(GC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC(=O)OC1=CC2=CC=CC=C2C=C1
• Uses: 2-Naphthyl Acetate is used in the staining of gels for esterase activity in the biological laboratories. An esterase substrate. 2-Naphthyl acetate has been used as a substrate:in substrate sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) to examine the composition of lipases in larvae and adult specimensin the preparation of zymograms to identify proteins with lipase activityto measure non-specific esterase activity and β-esterase enzyme activity

Technology Process of 2-Naphthyl acetate

There total 50 articles about 2-Naphthyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

acetic acid (64-19-7,77671-22-8) + β-naphthol (135-19-3) → naphthalen-2-yl acetate (1523-11-1)

Guidance literature:

acetic acid; With trifluoroacetic anhydride; indium(III) chloride; at 20 ℃;

β-naphthol; at 20 ℃; for 0.166667h;

DOI:10.1016/S0040-4039(03)01641-1

Reference yield: 99.0%

vinyl acetate (108-05-4,9003-20-7) + β-naphthol (135-19-3) → naphthalen-2-yl acetate (1523-11-1)

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; In neat (no solvent); at 70 - 140 ℃; for 0.183333h; Microwave irradiation;

DOI:10.1039/c5nj01436k

Reference yield: 99.0%

acetyl chloride (75-36-5) + β-naphthol (135-19-3) → naphthalen-2-yl acetate (1523-11-1)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; Schlenk technique; Inert atmosphere;

DOI:10.1002/ejoc.201800312

upstream raw materials:

pyridine

benzoyl chloride

acetic acid

β-naphthol

Downstream raw materials:

1-(2-hydroxy-1-naphthyl)ethan-1-one

1-(7-hydroxy-1-naphthalenyl)ethanone

2-benzyloxynaphthalene

acetamide

Refernces

• 1、 Shamma,M. et al.. "". . p. 2907 - 2911. Retrieved 1977.
• 2、 Spassow. "-". . . Retrieved 1942.
• 3、 Vera, S.,Rodenas, E.. "INHIBITON EFFECT OF CATIONIC MICELLES ON THE BASIC HYDROLYSIS OF AROMATIC ESTERS". . p. 143 - 150. Retrieved 1986.
• 4、 Ueno et al.. "". . p. 864. Retrieved 1964.
• 5、 Mandal, Tanmoy,Yadav, Sudha,Choudhury, Joyanta. "Steric effect of NHC ligands in Pd(II)–NHC-catalyzed non-directed C–H acetoxylation of simple arenes". . . Retrieved 2021/09/06.
• 6、 Kumar, Pushpendra,Patil, Shripad M.,Tandon, Nitin,Tandon, Runjhun. "Magnetically recyclable silica-coated ferrite magnetite-K10montmorillonite nanocatalyst and its applications in O, N, and S-acylation reaction under solvent-free conditions". . p. 21291 - 21300. Retrieved 2021/07/01.