4-(Dimethylammonio)piperidinium dichloride

Base Information

• Chemical Name: 4-(Dimethylammonio)piperidinium dichloride
• CAS No.: 4876-59-9
• Molecular Formula: C7H16 N2 . 2 Cl H
• Molecular Weight: 201.139
• Hs Code.: 29333990
• European Community (EC) Number: 225-486-3
• Mol file: 4876-59-9.mol

Synonyms:4-(Dimethylammonio)piperidinium dichloride;SCHEMBL22777488

Chemical Property of 4-(Dimethylammonio)piperidinium dichloride

Chemical Property:

• Vapor Pressure: 0.929mmHg at 25°C
• Melting Point: 288-290℃
• Boiling Point: 179.7°Cat760mmHg
• Flash Point: 63.3°C
• PSA: 21.05000
• Density: g/cm³
• LogP: -6.56610
• Storage Temp.: Inert atmosphere,Room Temperature
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 200.0847040
• Heavy Atom Count: 11
• Complexity: 75

Purity/Quality:

Dimethyl-piperidin-4-yl-amine DiHCl ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C[NH+](C)C1CC[NH2+]CC1.[Cl-].[Cl-]
• Uses: Dimethyl-piperidin-4-yl-amine DiHCl

Technology Process of 4-(Dimethylammonio)piperidinium dichloride

There total 3 articles about 4-(Dimethylammonio)piperidinium dichloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.3%

4-dimethylaminopiperidine-1-carboxylic acid tert-butyl ester (412293-88-0) → 4-(dimethylamino)piperidine dihydrochloride (4876-59-9,172281-90-2)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; dichloromethane; water; for 8h; Cooling with ice;

Reference yield: 83.0%

→ 4-(dimethylamino)piperidine dihydrochloride (4876-59-9,172281-90-2)

Guidance literature:

Reference yield:

1-benzyl-N,N-dimethylpiperidin-4-amine dihydrochloride (4876-56-6) → 4-(dimethylamino)piperidine dihydrochloride (4876-59-9,172281-90-2)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In water; isopropyl alcohol; at 20 ℃; for 22h;

upstream raw materials:

1-benzyl-N,N-dimethylpiperidin-4-amine dihydrochloride

4-dimethylaminopiperidine-1-carboxylic acid tert-butyl ester

Downstream raw materials:

N,N-dimethyl-1-(4-nitrophenyl)piperidin-4-amine

(4-(dimethylamino)piperidin-1-yl)(4-nitrophenyl)methanone hydrochloride

[1-(4-Amino-phenyl)-piperidin-4-yl]-dimethyl-amine

tert-butyl 2-(2-(benzyloxy)-5-(4-(dimethylamino)piperidin-1-yl)benzamido)-4-phenylbenzoate

Refernces

• 1、 Diwan, Sachin S.,Dalvi, Sonali W.,Mulla, Hormuzd R.. "Cheap, efficient, and scalable synthesis of 4-N,N-dimethylaminopiperidine". experimental part. p. 273 - 277. Retrieved 2009/04/07.
• 2、 -. "2,3,4,5-TETRAHYDRO-1H-1,5-BENZODIAZEPINE DERIVATIVE AND MEDICINAL COMPOSITION". Page/Page column 84. . Retrieved 2010/11/30.