4-ACETAMIDOTHIOANISOLE

Base Information

• Chemical Name: 4-ACETAMIDOTHIOANISOLE
• CAS No.: 10352-44-0
• Molecular Formula: C9H11 N O S
• Molecular Weight: 181.258
• Hs Code.: 2930909090
• Mol file: 10352-44-0.mol

Synonyms:Acetanilide,4'-(methylthio)- (6CI,7CI,8CI); 4-(Acetylamino)thioanisole;4-(Methylthio)acetanilide; Methyl p-(acetylamino)phenyl sulfide; NSC 151370;p-Acetamidophenyl methyl sulfide

Chemical Property of 4-ACETAMIDOTHIOANISOLE

Chemical Property:

• Vapor Pressure: 1.1E-05mmHg at 25°C
• Melting Point: 128-130°C
• Boiling Point: 371℃
• PKA: 14.55±0.70(Predicted)
• Flash Point: 178℃
• PSA: 54.40000
• Density: 1.14
• LogP: 2.43990

Purity/Quality:

98%,99%, ^*data from raw suppliers

N-(4-(Methylthio)phenyl)acetamide 95+% ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-ACETAMIDOTHIOANISOLE

There total 22 articles about 4-ACETAMIDOTHIOANISOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

tungsten hexacarbonyl (14040-11-0) + 1-methylthio-4-nitro-benzene (701-57-5) + carbonic acid dimethyl ester (616-38-6) → 4'-(methylthio)acetanilide (10352-44-0)

Guidance literature:

With di(rhodium)tetracarbonyl dichloride; 1,3-bis-(diphenylphosphino)propane; sodium phosphate; sodium iodide; In water; at 120 ℃; for 24h; Inert atmosphere; Sealed tube;

DOI:10.1039/d1cc00047k

Reference yield: 92.0%

1-(4-(methylthio)phenyl)ethan-1-one oxime → 4'-(methylthio)acetanilide (10352-44-0)

Guidance literature:

1-(4-(methylthio)phenyl)ethan-1-one oxime; With triethylamine; In dichloromethane; at 20 ℃; for 0.0833333h; Sealed tube;

With potassium hydrogen difluoride; In water; at 20 ℃; for 2h; Sealed tube;

DOI:10.1002/chem.201905358

Reference yield: 91.0%

acetyl chloride (75-36-5) + 4-methylsulfanylaniline (104-96-1) → 4'-(methylthio)acetanilide (10352-44-0)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 1h; Inert atmosphere;

DOI:10.1021/acs.orglett.6b01250

upstream raw materials:

acetic anhydride

4-methylsulfanylaniline

dimethyl sulfate

4-acetamidothiophenol

Downstream raw materials:

N-(4-methanesulfonylphenyl)acetamide

N-(4-(methylsulfinyl)phenyl)acetamide

thioacetic acid-(4-methylsulfanyl-anilide)

4-methylsulfanylaniline

Refernces

• 1、 -. "Preparation method of acetamide compound". Paragraph 0035-0047. . Retrieved 2021/05/19.
• 2、 -. "Efficient nitriding reagent and application thereof". Paragraph 0140-0142. . Retrieved 2021/03/31.