2β,7-Diamino-1β-hydroxymitosene

Base Information

• Chemical Name: 2β,7-Diamino-1β-hydroxymitosene
• CAS No.: 98462-75-0
• Molecular Formula: C₁₄H₁₆N₄O₅
• Molecular Weight: 320.305
• Mol file: 98462-75-0.mol

Synonyms:2β,7-Diamino-1β-hydroxymitosene

Chemical Property of 2β,7-Diamino-1β-hydroxymitosene

Chemical Property:

Purity/Quality:

>95% ^*data from raw suppliers

cis-1-Hydroxy-2,7-diaminoMitosene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2β,7-Diamino-1β-hydroxymitosene

There total 17 articles about 2β,7-Diamino-1β-hydroxymitosene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

mitomycin C (50-07-7) → cis-1-hydroxy-2-acetamido-7-aminomitosene (54911-22-7) + trans-1-hydroxy-2,7-diaminomitosene (99745-88-7,78655-54-6) + 2β,7-Diamino-1β-hydroxymitosene (98462-75-0,78655-54-6) + 2,7-Diaminomitosene (92695-32-4)

Guidance literature:

With Tris-HOAc-buffer pH 5.50; 4-methoxyphenylhydrazine hydrochloride; In water; for 48h; Mechanism; Ambient temperature; other substrates, also with D₂O;

DOI:10.1021/jo00032a037

Reference yield: 30.0%

mitomycin C (50-07-7) → trans-1-hydroxy-2,7-diaminomitosene (99745-88-7,78655-54-6) + 2β,7-Diamino-1β-hydroxymitosene (98462-75-0,78655-54-6) + 7-aminoaziridinomitosene (103422-25-9)

Guidance literature:

In methanol; for 0.0833333h; at -1.00 V, Pt electrode vs. SCE, supporting electrolyte: 0.1 M NaClO₄;

DOI:10.1021/jo00015a016

Reference yield: 28.8%

mitomycin C (50-07-7) → trans-1-hydroxy-2,7-diaminomitosene (99745-88-7,78655-54-6) + 2β,7-Diamino-1β-hydroxymitosene (98462-75-0,78655-54-6) + 10-decarbamoyl-2,7-diaminomitosene (102587-27-9) + 2,7-Diaminomitosene (92695-32-4) + trans-10-decarbamoyl-1,10-dihydroxy-2,7-diaminomitosene (92761-61-0) + cis-10-decarbamoyl-1,10-dihydroxy-2,7-diaminomitosene (92761-60-9)

Guidance literature:

With chromium(II) perchlorate; 2-[Bis(2-hydroxyethyl)imino]-2-(hydroxymethyl)-1,3-propanediol Hydrochloride; In water; for 0.5h; Product distribution; Mechanism; Ambient temperature; other solvents, var. pH; other reaction partners;

upstream raw materials:

mitomycin C

7-aminoaziridinomitosene

2',3'-isopropylideneguanosine

N,N-Dimethylhydrazine

Downstream raw materials:

cis-N²-phenylacetyl-2,7-diamino-1-hydroxymitosene

C₄₀H₄₀N₁₀O₁₁

trans-N²-phenylacetyl-2,7-diamino-1-aminomitosene

trans-N²-phenylacetyl-2,7-diamino-1-azidomitosene

Refernces

• 1、 Paz, Manuel M.. "Reaction of reductively activated mitomycin C with aqueous bicarbonate: Isolation and characterization of an oxazolidinone derivative of cis-1-hydroxy-2,7-diaminomitosene". experimental part. p. 31 - 34. Retrieved 2010/04/02.
• 2、 Subramaniam,Kohn. "Comparative reactivities of mitomycin C, 7-(N-piperidino)mitomycin, and mitomycin A. The role of the C(7)substituent". . p. 10519 - 10526. Retrieved 2007/10/02.