7-aminoaziridinomitosene

Base Information

• Chemical Name: 7-aminoaziridinomitosene
• CAS No.: 103422-25-9
• Molecular Formula: C₁₄H₁₄N₄O₄
• Molecular Weight: 302.29
• Mol file: 103422-25-9.mol

Synonyms:7-aminoaziridinomitosene

Chemical Property of 7-aminoaziridinomitosene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-aminoaziridinomitosene

There total 2 articles about 7-aminoaziridinomitosene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

mitomycin C (50-07-7) → trans-1-hydroxy-2,7-diaminomitosene (99745-88-7,78655-54-6) + 2β,7-Diamino-1β-hydroxymitosene (98462-75-0,78655-54-6) + 7-aminoaziridinomitosene (103422-25-9)

Guidance literature:

In methanol; for 0.0833333h; at -1.00 V, Pt electrode vs. SCE, supporting electrolyte: 0.1 M NaClO₄;

DOI:10.1021/jo00015a016

Reference yield:

mitomycin A (4055-39-4) → 7-aminoaziridinomitosene (103422-25-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 55 percent / H₂ / PtO₂ / ethyl acetate / 2 h

2: 20 percent / methanolic NH₃ / dimethylformamide / 2 h / Ambient temperature

With ammonia; hydrogen; platinum(IV) oxide; In ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1021/jm00160a012

Reference yield: 20.0%

sodium hydrogencarbonate (144-55-8) + 7-aminoaziridinomitosene (103422-25-9) → C15H14N4O6 (1207530-65-1) + 2β,7-Diamino-1β-hydroxymitosene (98462-75-0,78655-54-6)

Guidance literature:

7-aminoaziridinomitosene; With sodium hydrogencarbonate; In water; acetonitrile; at 20 ℃; for 5h;

sodium hydrogencarbonate; With tert-butyldicarbonate; In methanol; water; acetonitrile; at 20 ℃; for 24h; Further stages;

DOI:10.1016/j.bmcl.2009.11.046

upstream raw materials:

mitomycin C

mitomycin A

Downstream raw materials:

trans-1-hydroxy-2,7-diaminomitosene

2β,7-Diamino-1β-hydroxymitosene

2,7-Diaminomitosene

1α-deuterio-2,7-diaminomitosene

Refernces

• 1、 Han, Insook,Kohn, Harold. "7-Aminoaziridinomitosenes: Synthesis, Structure, and Chemistry". . p. 4648 - 4653. Retrieved 2007/10/02.