Technology Process of (3S,4S,5S)-3-(4-nitro)benzoyloxy-4,5-epoxycyclohex-1-ene
There total 3 articles about (3S,4S,5S)-3-(4-nitro)benzoyloxy-4,5-epoxycyclohex-1-ene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
cis-1,2-epoxy-4-cyclohexene;
With
tert-Butyl peroxybenzoate; tetrakis(actonitrile)copper(I) hexafluorophosphate; (S)-3,3-dimethyl-N-[1-(quinolin-2-yl)ethylidene]butan-2-amine;
In
acetone;
at 25 ℃;
for 121h;
Inert atmosphere;
With
sodium methylate;
In
methanol;
for 2h;
Inert atmosphere;
4-nitro-benzoyl chloride;
With
triethylamine;
In
dichloromethane;
at 20 ℃;
optical yield given as %ee;
Inert atmosphere;
DOI:10.1021/ol901284v
- Guidance literature:
-
Multi-step reaction with 2 steps
1: tetrakis(actonitrile)copper(I) hexafluorophosphate; (S)-3,3-dimethyl-N-[1-(quinolin-2-yl)ethylidene]butan-2-amine / acetone / 25 °C
2: sodium methylate
With
tetrakis(actonitrile)copper(I) hexafluorophosphate; (S)-3,3-dimethyl-N-[1-(quinolin-2-yl)ethylidene]butan-2-amine; sodium methylate;
In
acetone;
1: Kharasch-Sosnovsky allylic oxidation;
DOI:10.1021/jo200698g
- Guidance literature:
-
Multi-step reaction with 2 steps
1: tetrakis(actonitrile)copper(I) hexafluorophosphate; (S)-3,3-dimethyl-N-[1-(quinolin-2-yl)ethylidene]butan-2-amine / acetone / 25 °C
2: sodium methylate
With
tetrakis(actonitrile)copper(I) hexafluorophosphate; (S)-3,3-dimethyl-N-[1-(quinolin-2-yl)ethylidene]butan-2-amine; sodium methylate;
In
acetone;
1: Kharasch-Sosnovsky allylic oxidation;
DOI:10.1021/jo200698g