8-amino-2,3-diphenylpyrido[3,4-b]pyrazine

Base Information

• Chemical Name: 8-amino-2,3-diphenylpyrido[3,4-b]pyrazine
• CAS No.: 788821-74-9
• Molecular Formula: C₁₉H₁₄N₄
• Molecular Weight: 298.347
• Mol file: 788821-74-9.mol

Synonyms:8-amino-2,3-diphenylpyrido[3,4-b]pyrazine

Chemical Property of 8-amino-2,3-diphenylpyrido[3,4-b]pyrazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 8-amino-2,3-diphenylpyrido[3,4-b]pyrazine

There total 11 articles about 8-amino-2,3-diphenylpyrido[3,4-b]pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

N-(2,3-diphenylpyrido[3,4-b]pyrazin-8-yl)benzophenone imine (1305317-09-2) → 8-amino-2,3-diphenylpyrido[3,4-b]pyrazine (788821-74-9)

Guidance literature:

With hydroxylamine hydrochloride; sodium acetate; In methanol; at 75 ℃; for 48h;

DOI:10.1055/s-0030-1259429

Reference yield: 23.0%

3,4,5-triaminopyridine (618439-82-0) + benzil (134-81-6) → 8-amino-2,3-diphenylpyrido[3,4-b]pyrazine (788821-74-9)

Guidance literature:

With sodium hydrogencarbonate; In 1,4-dioxane; water; for 6h; Reflux;

DOI:10.1055/s-0030-1259429

Reference yield:

3,4-diaminopyridine (54-96-6) → 8-amino-2,3-diphenylpyrido[3,4-b]pyrazine (788821-74-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 1,4-dioxane / 120 h / Reflux

2: hydrogen bromide; dihydrogen peroxide / water / 1 h / 80 °C

3: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; rac-BINAP; sodium t-butanolate / toluene / 12 h / 100 °C / Inert atmosphere

4: hydroxylamine hydrochloride; sodium acetate / methanol / 48 h / 75 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; rac-BINAP; hydroxylamine hydrochloride; hydrogen bromide; dihydrogen peroxide; sodium acetate; sodium t-butanolate; In 1,4-dioxane; methanol; water; toluene; 3: Buchwald reaction;

DOI:10.1055/s-0030-1259429

upstream raw materials:

3,4-diaminopyridine

3,4,5-triaminopyridine

benzil

3,4-diamino-5-bromopyridine

Downstream raw materials:

N-(2,3-diphenylpyrido[3,4-b]pyrazin-8-yl)-N'-ethylthiourea

N-(2,3-diphenylpyrido[3,4-b]pyrazin-8-yl)-N'-phenylurea

N-(2,3-diphenylpyrido[3,4-b]pyrazin-8-yl)-4-methoxybenzamide

N-[4-chloro-3-(trifluoromethyl)phenyl]-N'-(2,3-diphenylpyrido[3,4-b]pyrazin-8-yl)urea

Refernces