Technology Process of TH-1456
There total 9 articles about TH-1456 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
di-isopropyl azodicarboxylate; triphenylphosphine;
In
toluene;
at 0 - 20 ℃;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: trichlorophosphate / 1 h / 100 °C
2: hydrogenchloride; hydrogen / palladium 10% on activated carbon / ethanol; water; ethyl acetate / 3 h
3: triethylamine / dichloromethane / 0 - 20 °C
4: potassium tert-butylate / tetrahydrofuran; dichloromethane / 1 h / -50 °C
5: di-isopropyl azodicarboxylate; triphenylphosphine / toluene / 0 - 20 °C
With
hydrogenchloride; di-isopropyl azodicarboxylate; potassium tert-butylate; hydrogen; triethylamine; triphenylphosphine; trichlorophosphate;
palladium 10% on activated carbon;
In
tetrahydrofuran; ethanol; dichloromethane; water; ethyl acetate; toluene;
5: Mitsunobu reaction;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: acetic acid / water / -78 - 20 °C
2: trichlorophosphate / 1 h / 100 °C
3: hydrogenchloride; hydrogen / palladium 10% on activated carbon / ethanol; water; ethyl acetate / 3 h
4: triethylamine / dichloromethane / 0 - 20 °C
5: potassium tert-butylate / tetrahydrofuran; dichloromethane / 1 h / -50 °C
6: di-isopropyl azodicarboxylate; triphenylphosphine / toluene / 0 - 20 °C
With
hydrogenchloride; di-isopropyl azodicarboxylate; potassium tert-butylate; hydrogen; acetic acid; triethylamine; triphenylphosphine; trichlorophosphate;
palladium 10% on activated carbon;
In
tetrahydrofuran; ethanol; dichloromethane; water; ethyl acetate; toluene;
6: Mitsunobu reaction;