Imidazo[1,2-a]pyridin-2-ylmethanol

Base Information

• Chemical Name: Imidazo[1,2-a]pyridin-2-ylmethanol
• CAS No.: 82090-52-6
• Molecular Formula: C8H8N2O
• Molecular Weight: 148.164
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID60383760
• Wikidata: Q72485285
• Mol file: 82090-52-6.mol

Synonyms:imidazo[1,2-a]pyridin-2-ylmethanol;82090-52-6;Imidazo[1,2-a]pyridine-2-methanol;2-(HYDROXYMETHYL)IMIDAZO[1,2-A]PYRIDINE;(H-imidazo[1,2-a]pyridin-2-yl)methanol;MFCD06797471;{imidazo[1,2-a]pyridin-2-yl}methanol;imidazo(1,2-a]-pyridin-2-ylmethanol;imidazo[1,2-a]-pyridin-2-ylmethanol;SCHEMBL102061;DTXSID60383760;ROPHYEIJSUUKEO-UHFFFAOYSA-N;CS-D0301;Imidazo[1,2-a]pyridine-2-ylmethanol;AKOS000125181;Imidazo [1,2-a]pyridin-2-ylmethanol;Imidazo[1,2-a]pyridin-2-yl-methanol;FG-0428;2-hydroxymethyl-imidazo[1,2-a]pyridine;imidazo [1,2-a]-pyridin-2-ylmethanol;AM804376;SY034790;FT-0655749;EN300-44125;Imidazo[1,2-a]pyridin-2-ylmethanol, AldrichCPR;J-502072;Z228586390

Chemical Property of Imidazo[1,2-a]pyridin-2-ylmethanol

Chemical Property:

• Melting Point: 101.5-103.5 °C
• Refractive Index: 1.641
• PSA: 37.53000
• Density: 1.267 g/cm³
• LogP: 0.82660
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 148.063662883
• Heavy Atom Count: 11
• Complexity: 140

Purity/Quality:

99% ^*data from raw suppliers

Imidazo[1,2-a]pyridin-2-ylmethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 22-26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC2=NC(=CN2C=C1)CO

Technology Process of Imidazo[1,2-a]pyridin-2-ylmethanol

There total 5 articles about Imidazo[1,2-a]pyridin-2-ylmethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

ethyl 3-imidazo[1,2-a]pyridine-2-carboxylate (38922-77-9) → 2-hydroxymethyl-imidazo[1,2-a]pyridine (82090-52-6)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 1h;

Reference yield: 31.0%

→ 2-hydroxymethyl-imidazo[1,2-a]pyridine (82090-52-6)

Guidance literature:

Reference yield:

C10H10N2O2 (721426-33-1) → 2-hydroxymethyl-imidazo[1,2-a]pyridine (82090-52-6)

Guidance literature:

With sodium methylate; In methanol; for 0.75h;

upstream raw materials:

ethyl 3-imidazo[1,2-a]pyridine-2-carboxylate

2-aminopyridine

C₁₀H₁₀N₂O₂

Downstream raw materials:

imidazo[1,2-a]pyridine-2-carbaldehyde

TH-1456

2-chloromethylimidazo[1,2-a]pyridine

Refernces

• 1、 Feng, Song,Hong, Di,Wang, Baoxia,Zheng, Xiufang,Miao, Kun,Wang, Lisha,Yun, Hongying,Gao, Lu,Zhao, Shuhai,Shen, Hong C.. "Discovery of imidazopyridine derivatives as highly potent respiratory syncytial virus fusion inhibitors". supporting information. p. 359 - 362. Retrieved 2015/03/30.
• 2、 -. "HETEROARYL COMPOUNDS AND METHODS OF USE THEREOF". Page/Page column 49. . Retrieved 2012/07/27.