Osalmid

Base Information

• Chemical Name: Osalmid
• CAS No.: 526-18-1
• Molecular Formula: C13H11NO3
• Molecular Weight: 229.235
• Hs Code.: 2924299090
• European Community (EC) Number: 208-385-9
• NSC Number: 93960
• UNII: 89741L759Z
• DSSTox Substance ID: DTXSID0042244
• Nikkaji Number: J2.063J
• Wikidata: Q27270017
• NCI Thesaurus Code: C76608
• ChEMBL ID: CHEMBL389507
• Mol file: 526-18-1.mol

Synonyms:4'-hydroxysalicylanilide;Driol;Fumispore;osalmide;oxaphenamide

Chemical Property of Osalmid

Chemical Property:

• Appearance/Colour: White crystal
• Vapor Pressure: 2.12E-05mmHg at 25°C
• Melting Point: 179 °C
• Refractive Index: 1.71
• Boiling Point: 350.8 °C at 760 mmHg
• PKA: 8.40±0.30(Predicted)
• Flash Point: 165.9 °C
• PSA: 69.56000
• Density: 1.387 g/cm³
• LogP: 2.42310
• Storage Temp.: Sealed in dry,Room Temperature
• Water Solubility.: 916mg/L at 25℃
• XLogP3: 2.9
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 229.07389321
• Heavy Atom Count: 17
• Complexity: 261

Purity/Quality:

99% ^*data from raw suppliers

2-Hydroxy-N-(4-hydroxyphenyl)benzamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-36/37/38-42/43
• Safety Statements: 26-36/37

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)C(=O)NC2=CC=C(C=C2)O)O
• Recent ClinicalTrials: Safety and Efficacy Assessments of Osalmid in Multiple Myeloma

Technology Process of Osalmid

There total 5 articles about Osalmid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

4-amino-phenol (123-30-8) + salicylamide (65-45-2) → 2-hydroxy-N-(4-hydroxyphenyl)benzamide (526-18-1)

Guidance literature:

With thionyl chloride; In ethyl acetate; at 170 ℃; for 6h; Concentration; Temperature;

Reference yield: 50.0%

4-amino-phenol (123-30-8) + salicylic acid (69-72-7,25496-36-0,8052-31-1) → 2-hydroxy-N-(4-hydroxyphenyl)benzamide (526-18-1)

Guidance literature:

salicylic acid; With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 20 ℃; for 0.166667h;

4-amino-phenol; In tetrahydrofuran; Further stages.; Heating;

DOI:10.1016/j.bmc.2007.03.074

Reference yield:

4-amino-phenol (123-30-8) + phenyl Salicylate (118-55-8) → 2-hydroxy-N-(4-hydroxyphenyl)benzamide (526-18-1)

Guidance literature:

upstream raw materials:

2-acetoxy-benzoic acid-(4-hydroxy-anilide)

4-amino-phenol

phenyl Salicylate

salicylic acid

Downstream raw materials:

3-(4-hydroxy-phenyl)-benzo[e][1,3]oxazine-2,4-dione

2-methyl-3-(p-ethoxyphenyl)-2,3-dihydro-4H-1,3-benzoxazin-4-one

2-vinyloxybenzoic acid p-hydroxyanilide

2-hydroxybenzoic acid p-vinyloxyanilide

Refernces

• 1、 Kumar, Anil,Narasimhan, Balasubramanian,Kumar, Devinder. "Synthesis, antimicrobial, and QSAR studies of substituted benzamides". . p. 4113 - 4124. Retrieved 2008/03/11.