p-Anisidine hydrochloride

Base Information

• Chemical Name: p-Anisidine hydrochloride
• CAS No.: 20265-97-8
• Molecular Formula: C7H9NO•ClH
• Molecular Weight: 159.615
• Hs Code.: 2922299090
• European Community (EC) Number: 243-657-0
• UN Number: 2811
• UNII: 7C4R75N8VG
• DSSTox Substance ID: DTXSID3020093
• Wikidata: Q27268049
• ChEMBL ID: CHEMBL1524474
• Mol file: 20265-97-8.mol

Synonyms:4-anisidine;4-anisidine hydrochloride;4-anisidine monoacid conjugate;4-methoxyaniline;p-anisidine;para-anisidine

Chemical Property of p-Anisidine hydrochloride

Chemical Property:

• Appearance/Colour: BROWN-GREY CRYSTALLINE POWDER
• Melting Point: 216-219oC
• Boiling Point: 265.9°Cat760mmHg
• Flash Point: 114.6°C
• PSA: 35.25000
• Density: 1.23g/cm³
• LogP: 2.66060
• Storage Temp.: Store below +30°C.
• Water Solubility.: within almost transparency
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 159.0450916
• Heavy Atom Count: 10
• Complexity: 77
• Transport DOT Label: Poison

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Methoxyanilinehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T+
• Hazard Codes: T+
• Statements: 33-26/27/28
• Safety Statements: 45-36/37/39-28A-1

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)N.Cl

Technology Process of p-Anisidine hydrochloride

There total 37 articles about p-Anisidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

diethyl (4-methoxyphenyl)phosphoramidate (22700-44-3) → p-anisidine hydrochloride (20265-97-8)

Guidance literature:

With acetyl chloride; In methanol; at 0 - 20 ℃;

DOI:10.1080/00397919808005101

Reference yield: 99.4%

N-(4-methoxyphenyl)-2-chloroacetamide (22303-36-2) → p-anisidine hydrochloride (20265-97-8)

Guidance literature:

With thionyl chloride; In methanol; for 2h; Reflux;

DOI:10.1007/s11164-011-0327-6

Reference yield: 99.0%

tert-butyl N-(4-methoxyphenyl)carbamate (18437-68-8) → p-anisidine hydrochloride (20265-97-8)

Guidance literature:

With sulfuric acid; sodium chloride; In neat (no solvent); at 20 ℃; for 3h; Sealed tube;

DOI:10.1039/d1ob00728a

upstream raw materials:

m-Chlorobenzoyl chloride

4-methoxy-aniline

4-nitrobenzyl chloride

benzoyl chloride

Downstream raw materials:

6-methoxy-3-(4-methoxyphenyl)-3,4-dihydroquinazoline

4-methoxyformanilide

2-hydroxyimino-N-(4-methoxyphenyl)acetamide

3-(4-methoxyphenylamino)propanenitrile

Refernces

• 1、 Chen, Juncheng,Chiang, Cheng-Ming,He, Gu,Liu, Bo,Liu, Jie,Ouyang, Liang,Tang, Pan,Wang, Guan,Yang, Chengcan,Ye, Tinghong,Zhang, Jifa,Zhang, Jin,Zou, Ling. "Discovery of Novel Dual-Target Inhibitor of Bromodomain-Containing Protein 4/Casein Kinase 2 Inducing Apoptosis and Autophagy-Associated Cell Death for Triple-Negative Breast Cancer Therapy". . p. 18025 - 18053. Retrieved 2022/01/03.
• 2、 Gudun, Kristina A.,Hayrapetyan, Davit,Khalimon, Andrey Y.,Segizbayev, Medet,Slamova, Ainur,Zakarina, Raikhan. "Cobalt-Catalyzed Deoxygenative Hydroboration of Nitro Compounds and Applications to One-Pot Synthesis of Aldimines and Amides". . . Retrieved 2021/11/30.