Technology Process of Methisazone
There total 9 articles about Methisazone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2′-N,N-dimethylaminophenylacetylene;
With
iodine; oxygen;
In
dimethyl sulfoxide;
at 20 - 100 ℃;
for 6h;
thiosemicarbazide;
With
diethylamine;
In
dimethylsulfoxide-d6;
at 20 ℃;
for 3h;
DOI:10.1021/acs.joc.5b00581
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: methyllithium / tetrahydrofuran / 1.5 h / -78 °C / Inert atmosphere
1.2: 3.17 h / 20 °C / Inert atmosphere
2.1: tri tert-butylphosphoniumtetrafluoroborate; bis(dibenzylideneacetone)-palladium(0); 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 16 h / 20 °C / Glovebox; Inert atmosphere; Sealed tube
2.2: 16 h / 20 °C / Sealed tube; Inert atmosphere
3.1: hydrogenchloride / tetrahydrofuran; water / 5 h / 70 °C
4.1: acetic acid / 2 h / 120 °C
With
hydrogenchloride; methyllithium; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; bis(dibenzylideneacetone)-palladium(0); tri tert-butylphosphoniumtetrafluoroborate;
In
tetrahydrofuran; water;
DOI:10.1002/ejoc.201600143
