2-Amino-7-nitrofluorene

Base Information

• Chemical Name: 2-Amino-7-nitrofluorene
• CAS No.: 1214-32-0
• Molecular Formula: C13H10N2O2
• Molecular Weight: 226.235
• Hs Code.: 2921499090
• NSC Number: 12278
• UNII: 78Y7L7MM5P
• DSSTox Substance ID: DTXSID70153259
• Nikkaji Number: J36.293J
• Wikidata: Q83020116
• ChEMBL ID: CHEMBL167542
• Mol file: 1214-32-0.mol

Synonyms:2-amino-7-nitrofluorene

Chemical Property of 2-Amino-7-nitrofluorene

Chemical Property:

• Appearance/Colour: Crystalline Solid
• Vapor Pressure: 1.38E-08mmHg at 25°C
• Melting Point: 234-235 °C
• Refractive Index: 1.726
• Boiling Point: 458.4 °C at 760 mmHg
• Flash Point: 231 °C
• PSA: 71.84000
• Density: 1.392 g/cm³
• LogP: 3.85260
• Storage Temp.: Refrigerator
• Solubility.: DMSO (Slightly), Methanol (Very Slightly, Heated)
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 226.074227566
• Heavy Atom Count: 17
• Complexity: 315

Purity/Quality:

99% ^*data from raw suppliers

2-Amino-7-nitrofluorene ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1C2=C(C=CC(=C2)N)C3=C1C=C(C=C3)[N+](=O)[O-]
• Uses: A mutagenic aromatic nitro compound.

Technology Process of 2-Amino-7-nitrofluorene

There total 9 articles about 2-Amino-7-nitrofluorene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

2,7-dinitro-9H-fluorene (5405-53-8) → 2-amino-7-nitrofluorene (1214-32-0)

Guidance literature:

With formic acid; triethylamine; palladium on activated charcoal; for 0.666667h; Heating;

DOI:10.1021/jo035204n

Reference yield:

7-nitro-9H-fluorene-2-carboxylic acid (107942-62-1) → 2-amino-7-nitrofluorene (1214-32-0)

Guidance literature:

With sulfuric acid; In chloroform;

DOI:10.1021/jo01063a006

Reference yield:

2-nitro-9H-fluorene (607-57-8) → 2-amino-7-nitrofluorene (1214-32-0)

Guidance literature:

Multi-step reaction with 2 steps

1: HNO₃; acetic acid / 5 h / 20 °C

2: 57 percent / formic acid; triethylamine / Pd/C / 0.67 h / Heating

With formic acid; nitric acid; acetic acid; triethylamine; palladium on activated charcoal;

DOI:10.1021/jo035204n

upstream raw materials:

2-aminofluorene

2,7-dinitro-9H-fluorene

2-acetylaminofluorene

7-nitro-9H-fluorene-2-carboxylic acid

Downstream raw materials:

2-dimethylamino-7-nitrofluorene

N-(7-nitro-fluoren-2-yl)-toluene-4-sulfonamide

7-hydroxy-2-acetylaminofluorene

7-hydroxy-2-aminofluorene

Refernces

• 1、 Ritter, Clare L.,Malejka-Giganti, Danuta. "Nitroreduction of nitrated and C-9 oxidized fluorenes in vitro". . p. 1361 - 1367. Retrieved 1998.
• 2、 Cislak,Hamilton. "-". . p. 746,748. Retrieved 1931.
• 3、 Ritter,Decker,Malejka-Giganti. "Reductions of nitro and 9-oxo groups of environmental nitrofluorenes by the rat mammary gland in vitro". . p. 793 - 800. Retrieved 2007/10/03.