Technology Process of methyl (5-((5-((4-hydroxyphenethyl)carbamoyl)furan-3-yl)carbamoyl)furan-3-yl)carbamate
There total 8 articles about methyl (5-((5-((4-hydroxyphenethyl)carbamoyl)furan-3-yl)carbamoyl)furan-3-yl)carbamate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
dichloromethane; N,N-dimethyl-formamide;
at 20 ℃;
for 24h;
Inert atmosphere;
DOI:10.1016/j.bmc.2012.01.043
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 1 h / 20 °C / Inert atmosphere
1.2: 24 h / 20 °C / Inert atmosphere
2.1: lithium hydroxide / tetrahydrofuran; water / 3 h / 20 °C
2.2: pH 3
3.1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane; N,N-dimethyl-formamide / 24 h / 20 °C / Inert atmosphere
With
1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide;
In
tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.01.043
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: copper(l) iodide; potassium carbonate; N,N`-dimethylethylenediamine / toluene / 23 h / 110 °C / Inert atmosphere
2.1: hydrogenchloride / 1,4-dioxane; water / 20 °C
3.1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 1 h / 20 °C / Inert atmosphere
3.2: 24 h / 20 °C / Inert atmosphere
4.1: lithium hydroxide / tetrahydrofuran; water / 3 h / 20 °C
4.2: pH 3
5.1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane; N,N-dimethyl-formamide / 24 h / 20 °C / Inert atmosphere
With
hydrogenchloride; copper(l) iodide; 1-hydroxy-7-aza-benzotriazole; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; N,N`-dimethylethylenediamine;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmc.2012.01.043
