C₃₁H₂₈F₂N₅O₆S⁽¹⁺⁾*I^(1-)

Base Information

• Chemical Name: C₃₁H₂₈F₂N₅O₆S⁽¹⁺⁾*I^(1-)
• CAS No.: 1370637-82-3
• Molecular Formula: C₃₁H₂₈F₂N₅O₆S*I
• Molecular Weight: 763.561
• Mol file: 1370637-82-3.mol

Synonyms:C₃₁H₂₈F₂N₅O₆S⁽¹⁺⁾*I^(1-)

Chemical Property of C₃₁H₂₈F₂N₅O₆S⁽¹⁺⁾*I^(1-)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₁H₂₈F₂N₅O₆S⁽¹⁺⁾*I^(1-)

There total 12 articles about C₃₁H₂₈F₂N₅O₆S⁽¹⁺⁾*I^(1-) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

7-(N-4-methylbenzamide)-3-(chloromethyl)-8-oxo-5-oxo-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid diphenylmethyl ester (91177-27-4) → C31H28F2N5O6S(1+)*I(1-) (1370637-82-3)

Guidance literature:

Multi-step reaction with 4 steps

1: tert-butylhypochlorite / methanol; dichloromethane / -45 °C

2: pyridine; phosphorus pentachloride / methanol; dichloromethane / -40 °C

3: pyridine; trichlorophosphate / methanol; dichloromethane / -40 - 0 °C

4: sodium iodide / dichloromethane; acetone / 0 °C

With pyridine; tert-butylhypochlorite; phosphorus pentachloride; sodium iodide; trichlorophosphate; In methanol; dichloromethane; acetone;

DOI:10.1016/j.cclet.2012.01.014

Reference yield:

(6R,7R)-benzhydryl (7-(2-difluoromethylthio)acetamido)-3-(chloromethyl)-7-methoxy-8-oxo-5-oxa-1-aza-bicyclo[4,2,0]oct-2-ene-2-carboxylate (134237-56-2) + imidazo[1.2-b]pyridazine (766-55-2) → C31H28F2N5O6S(1+)*I(1-) (1370637-82-3)

Guidance literature:

With sodium iodide; In dichloromethane; acetone; at 0 ℃;

DOI:10.1016/j.cclet.2012.01.014

Reference yield:

6β-(4-toluamido)penicillanic acid (17028-66-9) → C31H28F2N5O6S(1+)*I(1-) (1370637-82-3)

Guidance literature:

Multi-step reaction with 11 steps

1.1: pyridine; methanesulfonyl chloride / -5 - 10 °C

2.1: sodium tungstate; dihydrogen peroxide / 0 °C

3.1: chloro-trimethyl-silane; triethylamine / 10 °C

4.1: triphenylphosphine / ethyl acetate / 78 °C

5.1: chlorine; sodium hydrogencarbonate / water; ethyl acetate / 20 - 25 °C

5.2: 25 °C

6.1: pyridine; chlorine / dichloromethane

7.1: diethylamine / -20 °C

8.1: tert-butylhypochlorite / methanol; dichloromethane / -45 °C

9.1: pyridine; phosphorus pentachloride / methanol; dichloromethane / -40 °C

10.1: pyridine; trichlorophosphate / methanol; dichloromethane / -40 - 0 °C

11.1: sodium iodide / dichloromethane; acetone / 0 °C

With pyridine; sodium tungstate; chloro-trimethyl-silane; tert-butylhypochlorite; phosphorus pentachloride; dihydrogen peroxide; chlorine; sodium hydrogencarbonate; methanesulfonyl chloride; diethylamine; triethylamine; triphenylphosphine; sodium iodide; trichlorophosphate; In methanol; dichloromethane; water; ethyl acetate; acetone;

DOI:10.1016/j.cclet.2012.01.014

upstream raw materials:

6β-(4-toluamido)penicillanic acid

C₂₉H₂₈N₂O₅S

C₂₉H₂₆N₂O₄

diphenylmethyl (2R,6R,7R)-3-methylene-7-[(4-methylbenzoyl)amino]-8-oxo-5-oxa-1-azabicyclo[4.2.0]octane-2-carboxylate

Refernces