Technology Process of (S)-tert-butyl (3-((6-bromo-2-((4-phenylbut-3-yn-2-yl)oxy)naphthalen-1-yl)ethynyl)pyridin-4-yl)carbamate
There total 7 articles about (S)-tert-butyl (3-((6-bromo-2-((4-phenylbut-3-yn-2-yl)oxy)naphthalen-1-yl)ethynyl)pyridin-4-yl)carbamate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(3-iodo-pyridin-4-yl)-carbamic acid tert-butyl ester;
With
copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); diisopropylamine;
at 20 ℃;
for 0.25h;
Inert atmosphere;
(S)-6-bromo-1-ethynyl-2-((4-phenylbut-3-yn-2-yl)oxy)naphthalene;
In
toluene;
at 20 ℃;
for 24.5h;
DOI:10.1039/c2cc35583c
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: bis-triphenylphosphine-palladium(II) chloride; diisopropylamine; copper(l) iodide / 48 h / 25 °C
2.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 12 h / 0 - 20 °C / Inert atmosphere
3.1: potassium carbonate / methanol / 1 h / 20 °C
4.1: diisopropylamine; copper(l) iodide; tetrakis(triphenylphosphine) palladium(0) / 0.25 h / 20 °C / Inert atmosphere
4.2: 24.5 h / 20 °C
With
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); di-isopropyl azodicarboxylate; potassium carbonate; diisopropylamine; triphenylphosphine;
In
tetrahydrofuran; methanol;
1.1: |Sonogashira Cross-Coupling / 2.1: |Mitsunobu Displacement / 4.1: |Sonogashira Cross-Coupling / 4.2: |Sonogashira Cross-Coupling;
DOI:10.1039/c2cc35583c
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 12 h / 0 - 20 °C / Inert atmosphere
2.1: potassium carbonate / methanol / 1 h / 20 °C
3.1: diisopropylamine; copper(l) iodide; tetrakis(triphenylphosphine) palladium(0) / 0.25 h / 20 °C / Inert atmosphere
3.2: 24.5 h / 20 °C
With
copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); di-isopropyl azodicarboxylate; potassium carbonate; diisopropylamine; triphenylphosphine;
In
tetrahydrofuran; methanol;
1.1: |Mitsunobu Displacement / 3.1: |Sonogashira Cross-Coupling / 3.2: |Sonogashira Cross-Coupling;
DOI:10.1039/c2cc35583c