22-N-(benzyloxycarbonylamino)-10,21-diiodo-12,12,13,13,14,14,15,15,16,16,17,17,18,18,19,19-hexadecafluorodocosanoic acid

Base Information

• Chemical Name: 22-N-(benzyloxycarbonylamino)-10,21-diiodo-12,12,13,13,14,14,15,15,16,16,17,17,18,18,19,19-hexadecafluorodocosanoic acid
• CAS No.: 888615-90-5
• Molecular Formula: C₃₀H₃₃F₁₆I₂NO₄
• Molecular Weight: 1029.38
• Mol file: 888615-90-5.mol

Synonyms:22-N-(benzyloxycarbonylamino)-10,21-diiodo-12,12,13,13,14,14,15,15,16,16,17,17,18,18,19,19-hexadecafluorodocosanoic acid

Chemical Property of 22-N-(benzyloxycarbonylamino)-10,21-diiodo-12,12,13,13,14,14,15,15,16,16,17,17,18,18,19,19-hexadecafluorodocosanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 22-N-(benzyloxycarbonylamino)-10,21-diiodo-12,12,13,13,14,14,15,15,16,16,17,17,18,18,19,19-hexadecafluorodocosanoic acid

There total 3 articles about 22-N-(benzyloxycarbonylamino)-10,21-diiodo-12,12,13,13,14,14,15,15,16,16,17,17,18,18,19,19-hexadecafluorodocosanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

10,19-diiodo-12,12,13,13,14,14,15,15,16,16,17,17,18,18,19,19-hexadecafluorononadecanoic acid (888615-87-0) + N-(Benzyloxycarbonyl)allylamine (5041-33-8) → 22-N-(benzyloxycarbonylamino)-10,21-diiodo-12,12,13,13,14,14,15,15,16,16,17,17,18,18,19,19-hexadecafluorodocosanoic acid (888615-90-5)

Guidance literature:

With sodium dithionite; sodium hydrogencarbonate; In water; acetonitrile; at 20 ℃;

DOI:10.1039/b513944a

Reference yield:

undecylenic acid (112-37-8) → 22-N-(benzyloxycarbonylamino)-10,21-diiodo-12,12,13,13,14,14,15,15,16,16,17,17,18,18,19,19-hexadecafluorodocosanoic acid (888615-90-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / zinc / CH₂Cl₂ / 2 h / Heating

2: 65 percent / sodium dithionite; sodium hydrogencarbonate / acetonitrile; H₂O / 20 °C

With sodium dithionite; sodium hydrogencarbonate; zinc; In dichloromethane; water; acetonitrile;

DOI:10.1039/b513944a

Reference yield:

1,8-diiodoperfluorooctane (335-70-6) → 22-N-(benzyloxycarbonylamino)-10,21-diiodo-12,12,13,13,14,14,15,15,16,16,17,17,18,18,19,19-hexadecafluorodocosanoic acid (888615-90-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / zinc / CH₂Cl₂ / 2 h / Heating

2: 65 percent / sodium dithionite; sodium hydrogencarbonate / acetonitrile; H₂O / 20 °C

With sodium dithionite; sodium hydrogencarbonate; zinc; In dichloromethane; water; acetonitrile;

DOI:10.1039/b513944a

upstream raw materials:

10,19-diiodo-12,12,13,13,14,14,15,15,16,16,17,17,18,18,19,19-hexadecafluorononadecanoic acid

N-(Benzyloxycarbonyl)allylamine

undecylenic acid

1,8-diiodoperfluorooctane

Downstream raw materials:

N-[1-(dodecylcarbamoyl)-4-(tert-butyloxycarbonylamino)butyl]-22-(benzyloxycarbonylamino)-12,12,13,13,14,14,15,15,16,16,17,17,18,18,19,19-hexadecafluorodocosanamide

22-N-(benzyloxycarbonylamino)-12,12,13,13,14,14,15,15,16,16,17,17,18,18,19,19-hexadecafluorodocosanoic acid

Refernces