2,4-Diphenylimidazole

Base Information

• Chemical Name: 2,4-Diphenylimidazole
• CAS No.: 670-83-7
• Molecular Formula: C15H12 N2
• Molecular Weight: 220.274
• Hs Code.: 2933299090
• NSC Number: 167196
• DSSTox Substance ID: DTXSID40304756
• Nikkaji Number: J102.727A
• Wikidata: Q72473254
• Pharos Ligand ID: 2A23D98NWLT5
• ChEMBL ID: CHEMBL327027
• Mol file: 670-83-7.mol

Synonyms:670-83-7;2,4-Diphenylimidazole;2,4-Diphenyl-1H-imidazole;2,5-Diphenyl-1H-imidazole;1H-Imidazole, 2,4-diphenyl-;2,5-Diphenylimidazole;2,4(5)-Diphenylimidazole;CHEMBL327027;MFCD07772899;Imidazole, 2,4-diphenyl-;NSC167196;2,4-Diphenylimidazol;Imidazole,4-diphenyl-;2,4-diphenyl imidazole;1H-Imidazole,4-diphenyl-;2,4-diphenyl-1H-imidazol;SCHEMBL528246;2,4-Diphenyl-1H-imidazole #;SCHEMBL16900284;DTXSID40304756;BDBM50133778;AKOS015904049;AKOS025117309;Imidazole, 2,4(or 2,5)-diphenyl-;AC-1516;AM85870;NSC-167196;PD189091;SY041700;TS-00502;A9007;CS-0156399;FT-0659011;2,4-diphenyl-1H-imidazole;67-08-3

Chemical Property of 2,4-Diphenylimidazole

Chemical Property:

• Appearance/Colour: Allmost white crystal
• Vapor Pressure: 3.01E-08mmHg at 25°C
• Melting Point: 164-166 °C(Solv: ethanol (64-17-5))
• Boiling Point: 461.2 °C at 760 mmHg
• PKA: 12.39±0.10(Predicted)
• Flash Point: 254.7 °C
• PSA: 28.68000
• Density: 1.149 g/cm³
• LogP: 3.74370
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 3.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 220.100048391
• Heavy Atom Count: 17
• Complexity: 229

Purity/Quality:

99% ^*data from raw suppliers

2,4-Diphenylimidazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=CN=C(N2)C3=CC=CC=C3

Technology Process of 2,4-Diphenylimidazole

There total 94 articles about 2,4-Diphenylimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-(2-oxo-2-phenylethyl)-3-phenyl-1,2,4-oxadiazol-5(4H)-one → 2,4-diphenyl-1H-imidazole (670-83-7)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; triphenylphosphine; In 1,4-dioxane; at 80 ℃; for 24h; Reagent/catalyst; Temperature;

DOI:10.1055/s-0034-1378320

Reference yield: 96.0%

1-[(4-methylphenyl)sulfonyl]-2,4-diphenyl-1H-imidazole (1078739-19-1) → 2,4-diphenyl-1H-imidazole (670-83-7)

Guidance literature:

With benzotriazol-1-ol; In methanol; at 20 ℃; for 12h;

DOI:10.1021/ja805079v

Reference yield: 86.0%

phenylglyoxal hydrate (1074-12-0) + benzaldehyde (100-52-7) → 2,4-diphenyl-1H-imidazole (670-83-7)

Guidance literature:

With ammonium acetate; triethylammonium acetate; In neat (no solvent); at 120 ℃; for 0.5h;

DOI:10.1080/00304948.2015.1088757

upstream raw materials:

2,5-diphenyloxazole

1-phenyl-2-hydroxyethanone

benzamidin

α-bromoacetophenone

Downstream raw materials:

(2,5-diphenyl-1⁽³⁾H-imidazol-4-yl)-methanol

2,4-diphenyl-5-phenylazo-1⁽³⁾H-imidazole

1-methyl-2,4-diphenyl-1H-imidazole

benzoyl-1 diphenyl-2,4 imidazole

Refernces

• 1、 Hua, Ruimao,Iqbal, Muhammad Asif,Lu, Le,Mehmood, Hina. "Base-promoted annulation of amidoximes with alkynes: Simple access to 2,4-disubstituted imidazoles". . . Retrieved 2020/09/17.
• 2、 Stone, Elizabeth A.,Mercado, Brandon Q.,Miller, Scott J.. "Structure and Reactivity of Highly Twisted N-Acylimidazoles". supporting information. p. 2346 - 2351. Retrieved 2019/04/10.