benzoyl-1 diphenyl-2,4 imidazole

Base Information

• Chemical Name: benzoyl-1 diphenyl-2,4 imidazole
• CAS No.: 99876-44-5
• Molecular Formula: C₂₂H₁₆N₂O
• Molecular Weight: 324.382
• Mol file: 99876-44-5.mol

Synonyms:benzoyl-1 diphenyl-2,4 imidazole

Chemical Property of benzoyl-1 diphenyl-2,4 imidazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzoyl-1 diphenyl-2,4 imidazole

There total 6 articles about benzoyl-1 diphenyl-2,4 imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

-1 phenyl-5 tetrazole (95932-17-5) → 3,5-Diphenylpyrazole (1145-01-3) + (2,5-Diphenyl-imidazol-1-yl)-phenyl-methanone (99876-45-6) + benzoyl-1 diphenyl-2,4 imidazole (99876-44-5) + (3,5-diphenyl-1H-pyrazol-1-yl)(phenyl)methanone (71296-95-2) + N-((Z)-3-oxo-1,3-diphenylprop-1-en-1-yl)benzamide (23112-19-8) + (E)-1,3-Diphenyl-3-(5-phenyl-tetrazol-1-yl)-propenone (99876-46-7)

Guidance literature:

In 1,2-dichloro-benzene; at 160 ℃; for 8h; Product distribution; p-methoxy- and p-nitro-substituted β-tetrazolyl-trans-benzalacetophenones; effect of solvent (benzene, EtOH, aq. EtOH, CH3COOH, CF3COOH, pyridine) and other reagents (PPh3, copper);

Reference yield:

benzoyl chloride (98-88-4) + NSC 167196 (670-83-7) → benzoyl-1 diphenyl-2,4 imidazole (99876-44-5)

Guidance literature:

NSC 167196; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; for 0.166667h; Inert atmosphere;

benzoyl chloride; In tetrahydrofuran; mineral oil; at 0 - 23 ℃; Inert atmosphere;

DOI:10.1021/acs.orglett.9b00624

Reference yield:

benzamidin (618-39-3) → benzoyl-1 diphenyl-2,4 imidazole (99876-44-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: N,N-dimethyl-formamide

2.1: sodium hydride / mineral oil; tetrahydrofuran / 0.17 h / 0 °C / Inert atmosphere

2.2: 0 - 23 °C / Inert atmosphere

With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;

DOI:10.1021/acs.orglett.9b00624

upstream raw materials:

-1 phenyl-5 tetrazole

benzamidin

benzoyl chloride

NSC 167196

Downstream raw materials:

(2,5-Diphenyl-imidazol-1-yl)-phenyl-methanone

Refernces

• 1、 Cherton, Jean-Claude,Bazinet, Marc,Bolze, Marie-Madeleine,Lanson, Marc,Desbene, Paul-Louis. "Reactivite du nucleophile azoture vis-a-vis de cations heterocycliques aromatiques. VIII. Rearrangement de β-tetrazolo-trans-benzalacetophenones". . p. 2601 - 2607. Retrieved 2007/10/02.