1-(4-chlorophenyl)-4-iodobutane

Base Information

• Chemical Name: 1-(4-chlorophenyl)-4-iodobutane
• CAS No.: 160341-87-7
• Molecular Formula: C₁₀H₁₂ClI
• Molecular Weight: 294.563
• Mol file: 160341-87-7.mol

Synonyms:1-(4-chlorophenyl)-4-iodobutane

Chemical Property of 1-(4-chlorophenyl)-4-iodobutane

Chemical Property:

Purity/Quality:

95%-98% ^*data from raw suppliers

1-(4-Iodobutyl)-4-chlorobenzene 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(4-chlorophenyl)-4-iodobutane

There total 4 articles about 1-(4-chlorophenyl)-4-iodobutane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

4-(p-chlorophenyl)-1-butene (3047-24-3) → 1-(4-chlorophenyl)-4-iodobutane (160341-87-7)

Guidance literature:

4-(p-chlorophenyl)-1-butene; With iron(III) chloride; tributylphosphine; copper(I) bromide; cyclopentylmagnesium bromide; In diethyl ether; at -20 ℃; for 0.0833333h; Inert atmosphere;

With cyclopentylmagnesium bromide; In diethyl ether; at -20 ℃; for 1h; Inert atmosphere;

With iodine; In diethyl ether; at -20 ℃; for 0.166667h; Inert atmosphere;

DOI:10.1021/ja206745w

Reference yield: 70.0%

4-(p-chlorophenyl)-1-butanol (19967-22-7) → 1-(4-chlorophenyl)-4-iodobutane (160341-87-7)

Guidance literature:

With 1H-imidazole; iodine; triphenylphosphine; In dichloromethane; at 20 ℃; for 3h; Inert atmosphere;

DOI:10.1002/anie.201905986

Reference yield: 25.0%

4-(4-chlorophenyl)-4-oxobutanoic acid (3984-34-7) → 1-(4-chlorophenyl)-4-iodobutane (160341-87-7)

Guidance literature:

With Dimethylphenylsilane; iodine; indium(III) acetate; In chloroform; at 60 ℃; for 5h; Inert atmosphere; Sealed tube;

DOI:10.1246/cl.150686

upstream raw materials:

4-(p-chlorophenyl)-1-butene

chlorobenzene

4-(4-chlorophenyl)-4-oxobutanoic acid

4-(p-chlorophenyl)-1-butanol

Downstream raw materials:

Methyl 1-[4-(4-chlorophenyl)butyl]cyclohex-3-enecarboxylate

Refernces

• 1、 Sakai, Norio,Kobayashi, Taichi,Ogiwara, Yohei. "One-pot synthesis of tetralin derivatives from 3-benzoylpropionic acids: Indium-catalyzed hydrosilylation of ketones and carboxylic acids and intramolecular cyclization". . p. 1503 - 1505. Retrieved 2015/11/24.