2,4-DIAMINO-PYRIMIDINE-5-CARBALDEHYDE

Base Information

• Chemical Name: 2,4-DIAMINO-PYRIMIDINE-5-CARBALDEHYDE
• CAS No.: 20781-06-0
• Molecular Formula: C5H6N4O
• Molecular Weight: 138.129
• Hs Code.: 2933599090
• Mol file: 20781-06-0.mol

Synonyms:2,4-Diaminopyrimidine-5-carboxaldehyde;2,6-Diamino-5-pyrimidinecarboxaldehyde;NSC 211353;2,4-Diamino-5-formylpyrimidine;

Chemical Property of 2,4-DIAMINO-PYRIMIDINE-5-CARBALDEHYDE

Chemical Property:

• Appearance/Colour: Yellow solid
• Vapor Pressure: 6.75E-11mmHg at 25°C
• Melting Point: 274-276 °C
• Refractive Index: 1.723
• Boiling Point: 468.3 °C at 760 mmHg
• PKA: 5.32±0.10(Predicted)
• Flash Point: 237 °C
• PSA: 94.89000
• Density: 1.5 g/cm³
• LogP: 0.61590
• Storage Temp.: Refrigerator
• Solubility.: DMSO, Methanol

Purity/Quality:

98%,99%, ^*data from raw suppliers

2,4-Diaminopyrimidine-5-carboxaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 36/37/38-43-36-22
• Safety Statements: 26-36/37/39-36/37

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,4-DIAMINO-PYRIMIDINE-5-CARBALDEHYDE

There total 5 articles about 2,4-DIAMINO-PYRIMIDINE-5-CARBALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

2,4-diamino-pyrimidine-5-carbonitrile (16462-27-4) → 2,4-diamino-5-pyrimidinecarboxaldehyde (20781-06-0)

Guidance literature:

With hydrogen; In methanol; at 20 ℃; for 24h;

Reference yield: 78.0%

formic acid (64-18-6) + 2,4-diamino-pyrimidine-5-carbonitrile (16462-27-4) → 2,4-diamino-5-pyrimidinecarboxaldehyde (20781-06-0)

Guidance literature:

With Raney Nickel; In water; for 3 - 4h; Reflux;

DOI:10.1016/j.bmcl.2012.02.019

Reference yield: 59.0%

2,4-diaminopyrimidine (156-81-0) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 2,4-diamino-5-pyrimidinecarboxaldehyde (20781-06-0)

Guidance literature:

N,N-dimethyl-formamide; With trichlorophosphate; at 25 ℃; for 0.25h; Cooling with ice;

2,4-diaminopyrimidine; at 0 - 25 ℃; for 24h;

DOI:10.1016/j.ejmech.2017.05.010

upstream raw materials:

2,4-diamino-pyrimidine-5-carbonitrile

formic acid

2,4-diaminopyrimidine

N,N-dimethyl-formamide

Downstream raw materials:

2,7-diamino-6-(2,6-dichlorophenyl)-pyrido[2,3-d]-pyrimidine

6-(2,3,5,6-tetramethyl-phenyl)-pyrido[2,3-d]pyrimidine-2,7-diamine

6-(3,5-dimethoxy-phenyl)-pyrido[2,3-d]pyrimidine-2,7-diamine

2,7-diamino-6-(2,6-dimethylphenyl)-pyrido[2,3-d]pyrimidine

Refernces

• 1、 Chen, Wenhua,Yao, Xue,Huang, Zhenghui,Mao, Fei,Guan, Longfei,Tang, Yun,Jiang, Hualiang,Li, Jian,Huang, Jin,Jiang, Lubin,Zhu, Jin. "Novel dual inhibitors against FP-2 and PfDHFR as potential antimalarial agents: Design, synthesis and biological evaluation". supporting information. p. 250 - 254. Retrieved 2018/04/05.
• 2、 He, Haifeng,Xia, Hongying,Xia, Qin,Ren, Yanliang,He, Hongwu. "Design and optimization of N-acylhydrazone pyrimidine derivatives as E. coli PDHc E1 inhibitors: Structure-activity relationship analysis, biological evaluation and molecular docking study". . p. 5652 - 5661. Retrieved 2017/10/09.