3-carboxy-4-chlorophenylalanine

Base Information

• Chemical Name: 3-carboxy-4-chlorophenylalanine
• CAS No.: 13406-46-7
• Molecular Formula: C₁₀H₁₀ClNO₄
• Molecular Weight: 243.647
• Mol file: 13406-46-7.mol

Synonyms:

Chemical Property of 3-carboxy-4-chlorophenylalanine

Chemical Property:

• Vapor Pressure: 3.09E-09mmHg at 25°C
• Boiling Point: 459.5°Cat760mmHg
• Flash Point: 231.7°C
• Density: 1.504g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-carboxy-4-chlorophenylalanine

There total 5 articles about 3-carboxy-4-chlorophenylalanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2'-chloro-5-methylacetophenone (73129-52-9) → (RS)-3-carboxy-4-chlorophenylalanine (13406-46-7)

Guidance literature:

Multi-step reaction with 4 steps

1: NaOBr

2: (esterification)

3: (i) NBS, (PhCO)2O₂, CCl₄, (ii) /BRN= 783883/, NaOEt, EtOH

4: aq. HCl

With hydrogenchloride; sodium hypobromide;

DOI:10.1021/jm00315a040

Reference yield:

2-chloro-5-methyl-benzoic acid (6342-60-5) → (RS)-3-carboxy-4-chlorophenylalanine (13406-46-7)

Guidance literature:

Multi-step reaction with 3 steps

1: (esterification)

2: (i) NBS, (PhCO)2O₂, CCl₄, (ii) /BRN= 783883/, NaOEt, EtOH

3: aq. HCl

With hydrogenchloride;

DOI:10.1021/jm00315a040

Reference yield:

methyl 2-chloro-5-methylbenzoate (16220-95-4) → (RS)-3-carboxy-4-chlorophenylalanine (13406-46-7)

Guidance literature:

Multi-step reaction with 2 steps

1: (i) NBS, (PhCO)2O₂, CCl₄, (ii) /BRN= 783883/, NaOEt, EtOH

2: aq. HCl

With hydrogenchloride;

DOI:10.1021/jm00315a040

upstream raw materials:

sodium diethylacetamidomalonate

2'-chloro-5-methylacetophenone

2-chloro-5-methyl-benzoic acid

methyl 2-chloro-5-methylbenzoate

Refernces