2'-chloro-5-methylacetophenone

Base Information

• Chemical Name: 2'-chloro-5-methylacetophenone
• CAS No.: 73129-52-9
• Molecular Formula: C₉H₉ClO
• Molecular Weight: 168.623
• Mol file: 73129-52-9.mol

Synonyms:2'-chloro-5-methylacetophenone

Chemical Property of 2'-chloro-5-methylacetophenone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2'-chloro-5-methylacetophenone

There total 9 articles about 2'-chloro-5-methylacetophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C13H17ClO → 2'-chloro-5-methylacetophenone (73129-52-9)

Guidance literature:

With hydrogenchloride; In methanol; water; at 20 ℃;

DOI:10.1021/jm201061j

Reference yield:

para-chlorotoluene (106-43-4) + acetic anhydride (108-24-7) → 2'-chloro-5-methylacetophenone (73129-52-9)

Guidance literature:

With aluminium trichloride;

DOI:10.1021/ja01406a502

Reference yield:

2-chloro-5-methylphenyl trifluoromethanesulfonate (1131890-85-1) → 2'-chloro-5-methylacetophenone (73129-52-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 1,3-bis-(diphenylphosphino)propane; palladium diacetate; triethylamine / N,N-dimethyl-formamide / 3 h / 80 °C / Inert atmosphere

2: hydrogenchloride / methanol; water / 20 °C

With hydrogenchloride; 1,3-bis-(diphenylphosphino)propane; palladium diacetate; triethylamine; In methanol; water; N,N-dimethyl-formamide;

DOI:10.1021/jm201061j

upstream raw materials:

2-amino-5-methyl-acetophenone

para-chlorotoluene

acetic anhydride

acetyl chloride

Downstream raw materials:

2-(2-chloro-5-methylphenyl)-1,2-propene

Diethyl-acetamido(3-carbomethoxy-4-chlorobenzyl)malonat

(RS)-3-carboxy-4-chlorophenylalanine

5-bromomethyl-2-chloro-benzoic acid methyl ester

Refernces

• 1、 Valenta,Jilek,Pomykacek,et al.. "Noncataleptic potential neuroleptics: 2-methyl-10-(4-methylpiperazino)- and -10-[4-(2-hydroxyethyl)piperazino]-10,11-dihydrodibenzo[b,f]thiepin". . p. 2677 - 2688. Retrieved 2007/10/05.